Hazel B. Nichols

BackgroundFertility preservation (FP) may be underused after cancer diagnosis because of uncertainty around delays to cancer treatment and subsequent reproductive success.MethodsWomen aged 15 to 39 years diagnosed with cancer between 2004 a…

ObjectiveBlack women suffer a higher mortality from endometrial cancer (EC) than White women. Potential biological causes for this disparity include a higher prevalence of obesity and more lethal histologic/molecular subtypes. We hypothesiz…

Study questionIs there an association between fertility status, method of conception and the risks of birth defects and childhood cancer?Summary answerThe risk of childhood cancer had two independent components: (i) method of conception and…

Cigarette smoking is a known cause of many cancers, yet epidemiologic studies have found protective associations with the risk of four "estrogen-related" malignancies: endometrial cancer, endometrioid and clear cell ovarian cancers, and thy…

PurposeExcess embryos transferred (ET) (> plurality at birth) and fetal heartbeats (FHB) at 6 weeks' gestation are associated with reductions in birthweight and gestation, but prior studies have been limited by small sample sizes and limite…

Study questionWhat is the association between ART conception and treatment parameters and the risk of birth defects?Summary answerCompared to naturally conceived singleton infants, the risk of a major nonchromosomal defect among ART singlet…

PurposeIn the United States, hysterectomies and oophorectomies are frequently performed before menopause for benign conditions. The procedures are associated with reduced breast cancer-specific mortality among White women. The relationship …

Black women experience higher rates of hysterectomy than other women in the United States. Although research indicates that premenopausal hysterectomy with bilateral oophorectomy decreases the risk of breast cancer in black women, it remain…

ObjectiveTo estimate whether the protective effect of premenopausal bilateral oophorectomy on breast cancer risk is mitigated by estrogen therapy use after surgery.MethodsIn pooled data from four population-based case-control studies spanni…

Bilateral oophorectomy is often performed during hysterectomy for benign conditions and can reduce breast cancer risk by 20%-50% when performed at younger ages. Accuracy of estimating the decrease in breast cancer risk associated with bilat…

Abstract Background: Bilateral oophorectomy at early ages (<40 years) is recognized to lower breast cancer risk. Among U.S. women, oophorectomy is often performed with hysterectomy for benign conditions such as endometriosis and uterine …

Bilateral oophorectomy is often performed during hysterectomy for benign conditions and can reduce breast cancer risk by 20%–50 % when performed at younger ages. Accuracy of estimating the decrease in breast cancer risk associated with bila…