Tang S

Abstract Adult stem cells are thought to drive the regenerative potential of the endometrium and contribute to the pathogenesis of endometriosis, however, their identity and defining features remain to be characterized. Here, we used in…

Adult stem cells are thought to drive the regenerative potential of the endometrium and contribute to the pathogenesis of endometriosis; however, their identity and defining features remain to be characterized. Here, we used in vivo and in …

BackgroundOvarian cancer remains the most lethal gynecological cancer, with fewer than 50% of patients surviving more than 5 years after diagnosis. This study aimed to analyze the global epidemiological trends of ovarian cancer from 1990 to…

Endometriosis, defined as the ectopic growth of endometrial tissue outside of the uterine cavity, is an inflammatory and hormone-dependent disease that causes excruciating pelvic pain, infertility, and significantly decreases quality of lif…

Hormonal fluctuations in women have major impacts on organ physiology, contributing to well-recognized sex differences in disease susceptibility and manifestations, as well as therapeutic responses. Yet, most experimental studies and precli…

IntroductionDanshen injection, derived from the traditional Chinese medicine Salvia miltiorrhiza Bunge, has been clinically validated for its safety and efficacy in treating various gynecological diseases, including endometrial fibrosis cau…

Endometrial organoids are a powerful, 3D in vitro system for studying reproductive function and disease since they are more physiologically representative than 2D cell models. However, optimal methods for the analysis of individual organoid…

The application of machine learning in clinical medicine requires systematic evaluation across diverse modeling paradigms. We benchmarked 10 models, including classic machine learning, tabular deep learning, and automated machine learning (…

Abstract Endometrial stem cells and their regenerative properties are implicated in the pathogenesis of endometriosis. Using single-cell RNA sequencing of the adult mouse endometrium, we identified a sub-population of aldehyde dehydrogenas…

ObjectiveTo compare surgical outcomes of laparoendoscopic single-site myomectomy (LESS-M) for uterine myomas using barbed suture versus conventional suture.MethodsData were collected from all women with uterine myomas who underwent LESS-M a…

ObjectiveThe association between anti-Müllerian hormone (AMH) levels and embryonic aneuploidy rates was investigated by analyzing clinical and embryo laboratory data from patients with preimplantation genetic testing for aneuploidy (PGT-A).…

BackgroundOvarian cancer patients with elevated serum CA125 levels after operation have a high incidence of relapse or metastasis. 18F-FDG PET/CT is an effective imaging method for identifying recurrent or metastatic lesions. This study sys…

AIM: To explore whether preoperative vaginal dysbiosis influences the recurrence of endometrial polyps after hysteroscopic polypectomy. DESIGN: Retrospective-prospective observational cohort study. METHODS: A total of 679 patients from ou…

Endometrial decidualization, a prerequisite for successful pregnancies, relies on transcriptional reprogramming driven by progesterone receptor (PR) and bone morphogenetic protein (BMP)-SMAD1/SMAD5 signaling pathways. Despite their critical…

EPH receptors (EPHs), the largest family of tyrosine kinases, phosphorylate downstream substrates upon binding of ephrin cell surface-associated ligands. In a large cohort of endometriotic lesions from individuals with endometriosis, we fou…

Endometriosis is linked to increased infertility and pregnancy complications due to defective endometrial decidualization. We hypothesized that identification of altered signaling pathways during decidualization could identify the underlyin…

Endometriosis is a common and debilitating disease, affecting ∼170 million women worldwide. Affected patients have limited therapeutic options such as hormonal suppression or surgical excision of the lesions, though therapies are often not …

RationaleLobular endocervical glandular hyperplasia is a rare proliferative lesion of the endocervical glands with an unclear pathogenesis. The condition lacks specific clinical manifestations and signs and often leading to clinical underdi…

BACKGROUND: Total laparoscopic hysterectomy (TLH) is the most commonly performed gynaecological surgery. However, the difficulty of the operation varies depending on the patient and surgeon. Subsequently, patient's outcomes and surgical eff…

BackgroundTo explore whether SARS-CoV-2 infection affects the pregnancy outcomes of assisted reproductive techniques (ART).MethodsA prospective cohort study recruited patients for embryo transfer from December 01, 2022, to December 31, 2022…

The inflammatory response is a natural immune response that prevents microbial invasion and repairs damaged tissues. However, excessive inflammatory responses can lead to various inflammation-related diseases, posing a significant threat to…

BackgroundFor infertile women with overweight/obesity and insulin resistance (IR), it is uncertain whether intervention before infertility treatment can improve live birth rate (LBR). We implemented a factorial-design study to explore the e…

BackgroundTuberculosis (TB), a multisystemic disease with protean presentation, remains a major global health problem. Although concurrent pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) cases are commonly observed clini…

Estrogen-related receptor alpha (ERRα) plays an important role in endometrial cancer (EC) progression. However, the biological roles of ERRα in EC invasion and metastasis are not clear. This study aimed to investigate the role of ERRα and 3…

Endometrial tissue lines the inner cavity of the uterus and is under the cyclical control of estrogen and progesterone. It is a tissue that is composed of luminal and glandular epithelium, a stromal compartment, a vascular network, and a co…