Warren B. Nothnick

ORCID: 0000-0002-2349-1880 · 106 papers in corpus
lab-animal 2019
60S acidic ribosomal protein P1 (RPLP1) is elevated in human endometriotic tissue and in a murine model of endometriosis and is essential for endometriotic epithelial cell survival in vitro
Molecular human reproduction ·doi:10.1093/molehr/gaz065

Endometriosis is a female disease which is defined as the presence of ectopic endometrial tissue and is dependent on estrogen for its survival in these ectopic locations. Expression of the ribosomal protein large P1 (RPLP1) is associated wi…

2019
Faculty Opinions recommendation of Generation of immortalized human endometrial stromal cell lines with different endometriosis risk genotypes.
·doi:10.3410/f.735106325.793556973
lab-animal 2019
Human endometriotic lesion expression of the miR-144-3p/miR-451a cluster, its correlation with markers of cell survival and origin of lesion content
Scientific reports ·doi:10.1038/s41598-019-45243-7

Endometriosis is an inflammatory condition in which endometrial tissue grows in ectopic locations. Survival and growth of these ectopic lesions is associated with pain and infertility. MicroRNAs (miRNAs) have been postulated to play a role …

2018
Faculty Opinions recommendation of miR-31 and miR-145 as Potential Non-Invasive Regulatory Biomarkers in Patients with Endometriosis.
·doi:10.3410/f.732444269.793546457
review 2018
Future Directions in Endometriosis Research and Therapeutics
Current women's health reviews ·doi:10.2174/1573404813666161221164810

BACKGROUND: Endometriosis is a disease common among women of reproductive age characterized by pain, anxiety and infertility. Defined as the growth of endometrial tissue in ectopic locations, endometriosis remains an enigmatic disease for w…

lab-animal 2018
Macrophage Migration Inhibitory Factor Receptor, CD74, is Overexpressed in Human and Baboon ( Papio Anubis) Endometriotic Lesions and Modulates Endometriotic Epithelial Cell Survival and Interleukin 8 Expression
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719118766262

CD74 is the primary receptor for macrophage migration inhibitory factor (MIF). Although expression of MIF has been described in endometriotic lesions, the cellular localization and function of the MIF receptor, CD74, are poorly understood. …

review 2018
Matrix Metalloproteinases and Endometriosis: Their ROle in Disease Pathophysiology and Potential as Therapeutic Targets
·doi:10.2174/1573404813666171101161622

Background: The matrix metalloproteinase (MMP) system is a group of enzymes, function to modulate the tissue structure and degrade the extracellular matrix (ECM), a process required in cellular repair, proliferation, apoptosis, and angiogen…

2018
MIR-144/MIR-451 cluster expression, regulation and functional significance in endometriosis
·doi:10.1016/j.fertnstert.2018.07.1082
2017
Faculty Opinions recommendation of Up-regulation of ribosome biogenesis by MIR196A2 genetic variation promotes endometriosis development and progression.
·doi:10.3410/f.726868384.793528009
review 2017
MicroRNAs and Endometriosis: Distinguishing Drivers from Passengers in Disease Pathogenesis
Seminars in reproductive medicine ·doi:10.1055/s-0037-1599089

Endometriosis is a disease common in women of reproductive age, characterized by pelvic pain and infertility. Despite its prevalence, the factors and mechanisms which contribute to the development and survival of ectopic lesions remain unce…

2016
Faculty Opinions recommendation of Anti-TNF-α treatment for pelvic pain associated with endometriosis.
·doi:10.3410/f.717995776.793514465
2016
Faculty Opinions recommendation of A selective estrogen receptor-beta agonist causes lesion regression in an experimentally induced model of endometriosis.
·doi:10.3410/f.724924485.793514478
2016
Faculty Opinions recommendation of Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis.
·doi:10.3410/f.725322107.793514479
2016
Faculty Opinions recommendation of Effect of tumor necrosis factor-alpha on adhesion of human endometrial stromal cells to peritoneal mesothelial cells: an in vitro system.
·doi:10.3410/f.726138335.793514462
2016
Faculty Opinions recommendation of Estrogen receptor β modulates apoptosis complexes and the inflammasome to drive the pathogenesis of endometriosis.
·doi:10.3410/f.725917202.793514480
2016
Faculty Opinions recommendation of Innervation of ectopic endometrium in a rat model of endometriosis.
·doi:10.3410/f.723943961.793514466
2016
Faculty Opinions recommendation of Macrophage migration inhibitory factor antagonist blocks the development of endometriosis in vivo.
·doi:10.3410/f.718046860.793514469
2016
Faculty Opinions recommendation of Macrophage migration inhibitory factor is involved in ectopic endometrial tissue growth and peritoneal-endometrial tissue interaction in vivo: a plausible link to endometriosis development.
·doi:10.3410/f.723347620.793514470
2016
Faculty Opinions recommendation of Molecular and preclinical basis to inhibit PGE2 receptors EP2 and EP4 as a novel nonsteroidal therapy for endometriosis.
·doi:10.3410/f.725663823.793514476
2016
Faculty Opinions recommendation of Regulation of matrix metalloproteinases and their inhibitors in uterine endometrial cells of patients with and without endometriosis.
·doi:10.3410/f.722759412.793514463
2016
Faculty Opinions recommendation of Selective blockade of prostaglandin E2 receptors EP2 and EP4 signaling inhibits proliferation of human endometriotic epithelial cells and stromal cells through distinct cell cycle arrest.
·doi:10.3410/f.718403263.793514473
2016
Faculty Opinions recommendation of Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms.
·doi:10.3410/f.1161710.793514471
2016
Faculty Opinions recommendation of Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits adhesion of human endometriotic epithelial and stromal cells through suppression of integrin-mediated mechanisms.
·doi:10.3410/f.717993243.793514472
2016
Faculty Opinions recommendation of Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits invasion of human immortalized endometriotic epithelial and stromal cells through suppression of metalloproteinases.
·doi:10.3410/f.8074957.793514474
2016
Faculty Opinions recommendation of The treatment with a COX-2 specific inhibitor is effective in the management of pain related to endometriosis.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ·doi:10.3410/f.3541956.793514477