Williams, Christina

A key clinical problem is identifying the endometriosis patient whose pain is complicated by central nervous system sensitization, where conventional gynecologic treatment (e.g. hormonal therapy or surgery) may not completely alleviate the …

Background: Endometriosis is a complex condition that can negatively affect a woman’s quality of life, including her sleep. This study aims to assess the multifactorial variables associated with poorer quality of sleep in women with endomet…

OBJECTIVES: To determine if pain catastrophizing is independently associated with pain health-related quality-of-life in women with endometriosis, independent of potential confounders. METHODS: Analysis of cross-sectional baseline data from…

Background. Deep dyspareunia, a common symptom in endometriosis, has previously been associated with bladder or pelvic floor tenderness (BPFT), which suggests a role for central nervous system sensitization. The Central Sensitization Invent…

Background. The etiology of endometriosis-associated deep dyspareunia may include direct endometriosis-specific factors (e.g., Stage or invasiveness of disease) and/or indirect contributors such as bladder/pelvic floor dysfunction (e.g., re…

The etiology of deep dyspareunia in endometriosis is unclear. Our objective was to determine whether nerve bundle density in the cul-de-sac/uterosacrals (Zone II) is associated with deep dyspareunia in women with endometriosis. We conducted…