Stephanie Chen

No ORCID on file · 2 papers in corpus

observational 2024

Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions

American journal of human genetics ·doi:10.1016/j.ajhg.2024.04.011

To identify credible causal risk variants (CCVs) associated with different histotypes of epithelial ovarian cancer (EOC), we performed genome-wide association analysis for 470,825 genotyped and 10,163,797 imputed SNPs in 25,981 EOC cases an…

other 2020

Ovarian Cancer Risk Variants Are Enriched in Histotype-Specific Enhancers and Disrupt Transcription Factor Binding Sites

American journal of human genetics ·doi:10.1016/j.ajhg.2020.08.021

Quantifying the functional effects of complex disease risk variants can provide insights into mechanisms underlying disease biology. Genome-wide association studies have identified 39 regions associated with risk of epithelial ovarian cance…