Kiran L Sharma

ORCID: 0000-0002-1988-389X · 3 papers in corpus
article 2026
Identification of potent inhibitors of JUN N-terminal kinases for treatment of endometriosis and associated pain
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.2607561123

Endometriosis, defined as the ectopic growth of endometrial tissue outside of the uterine cavity, is an inflammatory and hormone-dependent disease that causes excruciating pelvic pain, infertility, and significantly decreases quality of lif…

other 2024
Identification of potent pan-ephrin receptor kinase inhibitors using DNA-encoded chemistry technology
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.2322934121

EPH receptors (EPHs), the largest family of tyrosine kinases, phosphorylate downstream substrates upon binding of ephrin cell surface-associated ligands. In a large cohort of endometriotic lesions from individuals with endometriosis, we fou…

2012
Significant role of estrogen and progesterone receptor sequence variants in gallbladder cancer predisposition: a multi-analytical strategy.
PloS one ·doi:10.1371/journal.pone.0040162

BackgroundCarcinoma of gallbladder (GBC) is an aggressive malignancy. The higher incidence of gallbladder cancer in women has been partly attributed to hormonal factors. Therefore the present study was designed to explore the role of geneti…