René Holm

ORCID: 0000-0003-4894-7765 · 2 papers in corpus

article 2016

Effect of cyclodextrin concentration on the oral bioavailability of danazol and cinnarizine in rats

·doi:10.1016/j.ejpb.2016.01.007

Cyclodextrins (CDs) are frequently used as an excipient to enhance the intestinal drug absorption of compounds with a low aqueous solubility. However, there exists an intricate interplay between opposing effects that determine the optimal d…

article 2008

Lipid-based Formulations for Danazol Containing a Digestible Surfactant, Labrafil M2125CS: In Vivo Bioavailability and Dynamic In Vitro Lipolysis

·doi:10.1007/s11095-008-9641-0

PurposeTo evaluate the use of Labrafil M2125CS as a lipid vehicle for danazol. Further, the possibility of predicting the in vivo behavior with a dynamic in vitro lipolysis model was evaluated.MethodsDanazol (28 mg/kg) was administered oral…