Chen L

BACKGROUND: Adenomyosis diagnosis and classification relies primarily on magnetic resonance imaging or pathological examination. Liquid biopsy has been widely applied in oncology but remains underexplored for adenomyosis. We aimed to identi…

OBJECTIVES: To investigate whether the CaMKKβ/AMPK/HIF-1α signaling pathway participates in angiogenesis in endometriosis by regulating mitophagy. METHODS: Human endometrial stromal cells (hEM15A) isolated from endometriosis patients and n…

BACKGROUND: Ovarian cancer remains one of the deadliest gynecologic malignancies. Poor outcomes largely reflect late diagnosis, marked inter- and intratumoral heterogeneity, and variable treatment response. METHODS: This review summarizes …

OBJECTIVE: To investigate the association between the dynamic trajectories of urinary human chorionic gonadotropin (hCG) and the risk of early miscarriage after embryo transfer. METHODS: In this prospective cohort study conducted in Hebei …

OBJECTIVE: To present two cases of primary ovarian squamous-cell carcinoma (POSCC) and describe a comprehensive review and analysis of the published related literature. METHODS: We reviewed the medical records of two patients with POSCC wh…

BACKGROUND: Idiopathic male infertility (IMI) accounts for 30%-40% of male infertility cases, yet the molecular networks associated with seminal plasma dysfunction and non-invasive biomarkers remain largely unclear. This study aimed to prel…

Early-stage endometrial cancer frequently shares overlapping clinical presentations and sonographic features with benign endometrial disorders, making early detection challenging. This retrospective study evaluated clinical characteristics,…

INTRODUCTION: Acupuncture has been explored as a potential intervention for POR; however, high-quality evidence is limited. This multicenter randomized trial evaluated the effect of acupuncture on the number of oocytes retrieved following c…

INTRODUCTION: Diminished ovarian reserve (DOR) is known to reduce the likelihood of achieving pregnancy or live births in women undergoing in vitro fertilization and embryo transfer (IVF-ET). Acupuncture maybe effective for DOR, but current…

Endometrioid intraepithelial neoplasia (EIN) is a preinvasive precursor of endometrial carcinoma, yet its recognition in secretory-phase endometrium remains diagnostically challenging. Current criteria for EIN diagnosis do not account for f…

Environmental estrogens, a group of exogenous endocrine-active compounds, are frequently present in animal feed, water, and husbandry environments. These compounds, which include synthetic xenoestrogens, phytoestrogens, and metalloestrogens…

BACKGROUND: Syndrome differentiation in Traditional Chinese Medicine (TCM) is pivotal to clinical practice and dictates the efficacy of medicinal treatments. However, precision diagnostic models for TCM syndromes, constructed from biomarker…

Endometriosis is a common gynecological disorder that requires accurate detection of ectopic lesions in laparoscopic images for effective diagnosis and treatment. However, existing deep learning-based detection methods face significant chal…

OBJECTIVE: To identify factors associated with clinical pregnancy and live birth in frozen embryo transfer (FET) cycles among women with adenomyosis and to develop internally validated prediction models using readily available clinical, lab…

Blood-based liquid biopsies hold transformative potential for non-invasive cancer management, but current approaches relying on rare circulating tumor components limit their broad clinical utility. Platelets, abundant in blood and mediating…

BACKGROUND: Endometriosis is a hormone-related gynecological disease and characterized by the invasion of endometrial cells outside the uterine cavity. OBJECTIVE: This study aimed to investigate the impact of goserelin acetate implants on …

OBJECTIVES: To evaluate the value of radiomics based on ultrasound in differentiating uterine fibroids (UFs) and uterine adenomyomas (AMs) and construct a noninvasive tool for this differentiation. METHODS: The clinical data and ultrasound…

OBJECTIVE: The aim of the present study was to analyze pregnancy outcomes among patients diagnosed with first-trimester decidual polyps (DPs) following fresh embryo transfer who underwent expectant management and to further explore risk fac…

Primary vaginal cancer is a rare malignant tumor; its pathogenesis remains unclear and only a limited number of cases have been documented in the literature. The present report outlines a rare case of primary vaginal endometrioid adenocarci…

BACKGROUND: Pro-EGCG has shown therapeutic promise for endometriosis, yet its immunoregulatory mechanisms remain unclear. Myeloid-derived suppressor cells (MDSCs) are key drivers of disease progression. This study investigates whether Pro-E…

BACKGROUNDS: Given the distinct pathogenic mechanisms of early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD), identifying disease-specific therapeutic targets for each subtype is particularly critical. METHODS:…

BACKGROUND: Environmental exposure to trace and heavy metals may influence female fertility, yet their impact on assisted reproductive outcomes remains poorly defined. Maternal diet can potentially modulate metal-related toxicity by influen…

Background/Objectives: Endometriosis manifests as ectopic endometrial tissue outside the uterine cavity. This lesion can sometimes appear at unusual anatomical sites or within the intestinal tract, growing and mimicking cancer. Such tumor-l…

BACKGROUND: Accurate diagnosis of rectal and perirectal lesions remains challenging, particularly for submucosal, necrotic, or anatomically complex masses where conventional endoscopic forceps biopsy (EFB) often yields insufficient tissue. …