John P Gibbs

ORCID: 0000-0001-8892-7318 · 1 paper in corpus

other 2020

Quantitative Assessment of Elagolix Enzyme-Transporter Interplay and Drug-Drug Interactions Using Physiologically Based Pharmacokinetic Modeling

Clinical pharmacokinetics ·doi:10.1007/s40262-019-00833-6

INTRODUCTION: Elagolix is approved for the management of moderate-to-severe pain associated with endometriosis. The aim of this analysis was to develop a physiologically based pharmacokinetic (PBPK) model that describes the enzyme-transport…