Leah M Prentice

No ORCID on file · 3 papers in corpus · active 2014-2017

Study types

  • other 2
  • article 1

Condition tags

  • mesh:D004715 2
  • endometriosis 2
other 2017
Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes
Nature genetics ·doi:10.1038/ng.3849

We studied the whole-genome point mutation and structural variation patterns of 133 tumors (59 high-grade serous (HGSC), 35 clear cell (CCOC), 29 endometrioid (ENOC), and 10 adult granulosa cell (GCT)) as a substrate for class discovery in …

article 2015
Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden
The Journal of Pathology ·doi:10.1002/path.4516

Endometriosis is a significant risk factor for clear cell and endometrioid ovarian cancers and is often found contiguous with these cancers. Using whole-genome shotgun sequencing of seven clear cell ovarian carcinomas (CCC) and targeted seq…

other 2014
Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc ·doi:10.1038/modpathol.2013.107

Ovarian endometrioid carcinomas and endometrial endometrioid carcinomas share many histological and molecular alterations. These similarities are likely due to a common endometrial epithelial precursor cell of origin, with most ovarian endo…