Margaret Lippincott

meta-analysis 2025

Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum

Nature genetics ·doi:10.1038/s41588-025-02156-8

Genome-wide association studies (GWASs) may help inform the etiology of infertility. Here, we perform GWAS meta-analyses across seven cohorts in up to 42,629 cases and 740,619 controls and identify 25 genetic risk loci for male and female i…

other 2024

Genome-wide analyses identify 21 infertility loci and over 400 reproductive hormone loci across the allele frequency spectrum

medRxiv : the preprint server for health sciences ·doi:10.1101/2024.03.19.24304530

Genome-wide association studies (GWASs) may help inform treatments for infertility, whose causes remain unknown in many cases. Here we present GWAS meta-analyses across six cohorts for male and female infertility in up to 41,200 cases and 6…

2020

The genetic architecture of sporadic and multiple consecutive miscarriage.

Nature communications ·doi:10.1038/s41467-020-19742-5

Miscarriage is a common, complex trait affecting ~15% of clinically confirmed pregnancies. Here we present the results of large-scale genetic association analyses with 69,054 cases from five different ancestries for sporadic miscarriage, 75…

2018

Large-scale meta-analysis highlights the hypothalamic-pituitary-gonadal axis in the genetic regulation of menstrual cycle length.

Human molecular genetics ·doi:10.1093/hmg/ddy317

The normal menstrual cycle requires a delicate interplay between the hypothalamus, pituitary and ovary. Therefore, its length is an important indicator of female reproductive health. Menstrual cycle length has been shown to be partially con…