Tsuyoshi Ohta

ORCID: 0000-0002-4819-4233 · 3 papers in corpus
other 2024
Profiling of metabolic dysregulation in ovarian cancer tissues and biofluids
Scientific reports ·doi:10.1038/s41598-024-72938-3

Ovarian cancer (OC) is the most lethal gynecologic cancer, mainly due to late diagnosis with widespread peritoneal spread at first presentation. We performed metabolomic analyses of ovarian and paired control tissues using capillary electro…

lab-animal 2023
Mechanism of Cell Death by Combined Treatment with an xCT Inhibitor and Paclitaxel: An Alternative Therapeutic Strategy for Patients with Ovarian Clear Cell Carcinoma
International journal of molecular sciences ·doi:10.3390/ijms241411781

Ovarian clear cell carcinoma (OCCC) is a rare subtype of epithelial ovarian carcinoma that responds poorly to chemotherapy. Glutathione (GSH) is a primary antioxidant, which protects cells against reactive oxygen species (ROS). High levels …

rct 2010
Effect of dienogest on estrogen-induced nitric oxide production in human umbilical vein endothelial cells and endothelium-dependent vasodilatation in postmenopausal women
Menopause (New York, N.Y.) ·doi:10.1097/gme.0b013e3181d273c7

OBJECTIVE: We investigated the effects of dienogest (DNG), which has a profile similar to that of natural progesterone (P4), on the favorable effects of estrogen in endothelial function. METHODS: (1) Human umbilical vein endothelial cells …