Varvel NH

ORCID: 0000-0002-0351-1098 · 2 papers in corpus · active 2023-2026
2026
Neuroinflammation and Disease: Pathways and Opportunities.
Annual review of pharmacology and toxicology ·doi:10.1146/annurev-pharmtox-062124-043519

We explore three emerging molecular pathways driving neuroinflammation in chronic and acute brain diseases: the EP2 receptor for prostaglandin E2, the CCR2 receptor for chemokine CCL2, and JAK/STAT signaling. Inflammation is now recognized …

2023
Preclinical development of an EP2 antagonist for post-seizure cognitive deficits.
Neuropharmacology ·doi:10.1016/j.neuropharm.2022.109356

Cognitive comorbidities can substantially reduce quality of life in people with epilepsy. Inflammation is a component of all chronic diseases including epilepsy, as well as acute events like status epilepticus (SE). Neuroinflammation is the…