Kevin D. Corbett

ABSTRACT During mitosis, the Bub1-Bub3 complex concentrates at kinetochores, the microtubule-coupling interfaces on chromosomes, where it contributes to spindle checkpoint activation, kinetochore-spindle microtubule interactions, and prote…

Ubiquitination and related pathways play crucial roles in protein homeostasis, signaling, and innate immunity 1-3 . In these pathways, an enzymatic cascade of E1, E2, and E3 proteins conjugates ubiquitin or a ubiquitin-like protein (Ubl) t…