Kjiana E. Schwab

Research questionAre endometrial stem/progenitor cells shed into uterine menstrual blood (UMB) and the peritoneal cavity in women with and without endometriosis during menstruation?DesignWomen with (n = 32) and without endometriosis (n = 29…

BACKGROUND: The existence of stem/progenitor cells in the endometrium was postulated many years ago, but the first functional evidence was only published in 2004. The identification of rare epithelial and stromal populations of clonogenic c…

Authors : Roxane A. Legaie, Kjiana E. Schwab, Caroline E. Gargett Abstract : Studies looking at the changes in gene expression from RNAseq data often make use of linear models. It is also common practice to focus on a subset of data for a c…

Background: Recently MSC have been identified in the regenerative endometrial lining of the uterus and specific markers (W5C5/SUSD2) for their prospective isolation identified. Postmenopausal endometrium is atrophic but regenerates with sys…

The pathogenesis of early-onset endometriosis has recently been revisited, sparked by the discovery of endometrial stem/progenitor cells and their possible role in endometriosis, and because maternal pregnancy hormone withdrawal following d…

Human endometrium is a highly regenerative tissue undergoing more than 400 cycles of growth, differentiation, and shedding during a woman's reproductive years. Endometrial regeneration is likely mediated by adult stem/progenitor cells. This…

The human endometrium (lining of the uterus) is a dynamic remodeling tissue undergoing more than 400 cycles of regeneration, differentiation, and shedding during a woman’s reproductive years. Endometrial regeneration also follows childbirth…

The human endometrium is a dynamic remodeling tissue undergoing more than 400 cycles of regeneration, differentiation and shedding during a woman's reproductive years. The co-ordinated and sequential actions of estrogen and progesterone dir…

The human endometrium has an immense regenerative capacity. Previously we identified a small population of clonogenic endometrial stromal cells or mesenchymal stem cells (MSC).1 Prospective isolation of MSC allows for their characterisation…

The human endometrium regenerates from the lower basalis layer, a germinal compartment that persists after menstruation to give rise to the new upper functionalis layer. Because adult stem cells are present in tissues that undergo regenerat…