Brandon R Grossardt

ObjectivesBilateral oophorectomy has commonly been performed in conjunction with hysterectomy even in women without a clear ovarian indication; however, oophorectomy may have long-term deleterious consequences. To better understand this sur…

ObjectiveTo study the association between bilateral oophorectomy and the rate of accumulation of multimorbidity.Patients and methodsIn this historical cohort study, the Rochester Epidemiology Project records-linkage system was used to ident…

OBJECTIVE: Unilateral oophorectomy (UO) is a common surgical practice, yet it remains understudied. We investigated trends in incidence rates, indications, and pathological differences in the right and left ovaries in women younger than 50 …

The neuroprotective effects of estrogen have been demonstrated consistently in cellular and animal studies but the evidence in women remains conflicted. We explored the window of opportunity hypothesis in relation to cognitive aging and dem…

Disclosures The authors report no commercial or financial relationships relevant to this article. Approximately 4.5 million women in the United States have undergone bilateral oophorectomy before reaching natural menopause, yet accumulating…

ObjectiveTo investigate the mortality associated with cardiovascular diseases and the effect of estrogen treatment in women who underwent unilateral or bilateral oophorectomy before menopause.DesignWe conducted a cohort study with long-term…

In the Mayo Clinic Cohort Study of Oophorectomy and Aging, women who had both ovaries removed before reaching natural menopause experienced a long-term increased risk of parkinsonism, cognitive impairment or dementia, and depressive and anx…