Chen H

BACKGROUND: Adenomyosis diagnosis and classification relies primarily on magnetic resonance imaging or pathological examination. Liquid biopsy has been widely applied in oncology but remains underexplored for adenomyosis. We aimed to identi…

AbstractThis study aimed to investigate whether an early LH surge during controlled ovarian stimulation (COS) affects pregnancy outcomes in patients with polycystic ovary syndrome (PCOS) undergoing assisted reproductive technology (ART) and…

BACKGROUND: Angiomyofibroblastoma (AMFB) is a relatively rare benign mesenchymal tumor predominantly observed in premenopausal women. We present a case of vulvar AMFB in a 29-year-old woman, with the tumor measuring approximately 6 cm in di…

Endometriosis is one of the most common benign gynecological disorders, characterized by persistent pain and challenges with fertility. Anoikis, a specific form of apoptosis, occurs when cells detach from the extracellular matrix. Recent re…

BACKGROUND: Gallbladder cancer (GBC) is a highly aggressive malignancy with an extremely poor prognosis, and its high postoperative recurrence rate is a major challenge affecting long-term patient survival. Accurately predicting individuali…

BackgroundThe relationship between gonadotropin-releasing hormone agonists (GnRH-as) and depression and suicide/self-injury (DASSI) remains controversial. This study aimed to investigate this potential association using data from the FDA Ad…

PurposeThis study aims to investigate the role of calcitonin gene-related peptide (CGRP) in corneal tissue repair in alkali burn and its underlying neuro-immune mechanisms.MethodsMouse corneal nerves were ablated via surgery or resiniferato…

BACKGROUND: Currently, CA125 combined with other biomarkers significantly outperforms CA125 alone in diagnosing endometriosis (EM), but the efficiency of combined diagnosis remains unclear. This network meta-analysis compared the accuracy o…

Iron overload induces cellular stress and is implicated in diverse pathological conditions. Nevertheless, the epigenetic mechanisms governing mammalian cellular responses to iron overload remain poorly characterized. Using multi-omics profi…

Endometrioid intraepithelial neoplasia (EIN) is a preinvasive precursor of endometrial carcinoma, yet its recognition in secretory-phase endometrium remains diagnostically challenging. Current criteria for EIN diagnosis do not account for f…

Endometrioid borderline tumors (EBTs) and seromucinous borderline tumors (SMBTs) are rare ovarian neoplasms with distinct histologic features. However, the molecular profiles of EBTs and SMBTs remain incompletely characterized. We performed…

BackgroundSyndrome differentiation in Traditional Chinese Medicine (TCM) is pivotal to clinical practice and dictates the efficacy of medicinal treatments. However, precision diagnostic models for TCM syndromes, constructed from biomarkers …

BackgroundPremature ovarian insufficiency (POI) significantly impairs female fertility and poses substantial health risks; however, its pathogenesis is incompletely understood, and effective therapeutic interventions are limited. Although g…

ObjectiveTo compare the effects of frozen-thawed embryo transfer at different times after hysteroscopic endometrial polyp resection on pregnancy outcomes and to provide evidence for individualized clinical treatment.MethodsThis study was a …

OBJECTIVE: To identify factors associated with clinical pregnancy and live birth in frozen embryo transfer (FET) cycles among women with adenomyosis and to develop internally validated prediction models using readily available clinical, lab…

Acute severe joint pain is a major symptom in gouty arthritis (GA), and its adequate treatment represents an unmet medical need. Mrgprb2, a specific mast cell receptor, has been implicated in the generation of chronic pain by mobilizing mas…

Phthalates (PAEs), typical endocrine-disrupting chemicals (EDCs) that accumulate in the human body to induce reproductive toxicity, have epidemiological links to endometriosis (EM), but the underlying micro-mechanisms remain unclear. Ferrop…

Infertility affects ~1 in 6 people of reproductive age and remains difficult to treat because causes are heterogeneous and diagnostics are incomplete. Recent evidence reframes the female reproductive tract as a low-biomass but biologically …

BACKGROUND: Ovarian ectopic pregnancy (OEP) is a rare and life-threatening condition that is typically diagnosed post-rupture. Its diagnosis and management become more complex when it is concurrent with ovarian endometrioma, as the latter m…

BACKGROUND: This study investigates how clinical factors and hormonal levels affect oocyte retrieval in modified natural cycles, aiming to improve understanding and enhance treatment protocols. METHODS: A retrospective analysis of data fro…

BACKGROUND: Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare (prevalence ~ 1:2 million), devastating genetic disorder characterized by progressive heterotopic ossification. Crucially, surgical trauma is a potent trigger for cata…

Endometriosis is a chronic gynecological disorder defined by the growth of endometrial-like tissue outside the uterus, driven by estrogen-dependent inflammation and progressive fibrosis. According to available data, remodeling and persisten…

Female reproductive disorders present significant challenges worldwide. Transfer RNA-derived small RNAs (tsRNAs), a structurally diverse class of non-coding RNAs mainly comprising tRNA halves (tiRNAs) and tRNA-derived fragments (tRFs), have…

BackgroundInfertility poses a significant health challenge for reproductive-aged women globally and could be shaped by both genetic risks and lifestyle factors. Existing studies predominantly focus on individual lifestyle components, while …

Ferroptosis is a potential target for the treatment of endometriosis (EMs). The role of andrographolide (AP) in the ferroptosis has gradually attracted attention, but its mechanism of action in endometriosis has not been clarified. Here we …