Marika Kangasniemi

2025

Women's Health Study (WENDY)-a protocol of a population-based study assessing gynecological and metabolic health in women in their mid-30s.

American Journal of Epidemiology ·doi:10.1093/aje/kwae230

The Women's Health Study (WENDY) was conducted to improve insights into women's health and health burden. It provides a unique, comprehensive data source that can be broadly utilized to understand gynecological symptoms, diseases, and their…

article 2022

Estradiol Valerate vs Ethinylestradiol in Combined Oral Contraceptives: Effects on the Pituitary-Ovarian Axis

·doi:10.1210/clinem/dgac150

CONTEXT: Limited studies have compared the effects of combined oral contraceptives (COCs) containing natural estrogens and synthetic ethinylestradiol (EE) on reproductive hormones. OBJECTIVE: To compare estradiol valerate (EV) + dienogest (…

article 2022

Ethinylestradiol in combined hormonal contraceptive has a broader effect on serum proteome compared with estradiol valerate: a randomized controlled trial

·doi:10.1093/humrep/deac250

STUDY QUESTION: Does an estradiol-based combined oral contraceptive (COC) have a milder effect on the serum proteome than an ethinylestradiol (EE)-based COC or dienogest (DNG) only? SUMMARY ANSWER: The changes in serum proteome were multifo…

article 2021

Effect of oral contraceptives containing estradiol valerate vs. ethinyl estradiol combined with dienogest on biomarkers of coagulation a randomized clinical trial

·doi:10.1530/endoabs.73.pep4.1

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

article 2020

Estradiol Valerate in COC Has More Favorable Inflammatory Profile Than Synthetic Ethinyl Estradiol: A Randomized Trial

·doi:10.1210/clinem/dgaa186

CONTEXT: Combined oral contraceptives (COCs) alter inflammatory status and lipid metabolism. Whether different estrogens have different effects is poorly understood. OBJECTIVE: We compared the effects of COCs containing ethinyl estradiol (E…

other 2020

Women with polycystic ovary syndrome present with altered endometrial expression of stanniocalcin-1†

Biology of reproduction ·doi:10.1093/biolre/ioz180

Stanniocalcin-1 (STC-1) is a pro-survival factor that protects tissues against stressors, such as hypoxia and inflammation. STC-1 is co-expressed with the endometrial receptivity markers, and recently endometrial STC-1 was reported to be dy…

2017

Niche matters: The comparison between bone marrow stem cells and endometrial stem cells and stromal fibroblasts reveal distinct migration and cytokine profiles in response to inflammatory stimulus.

PloS one ·doi:10.1371/journal.pone.0175986

ObjectiveIntrinsic inflammatory characteristics play a pivotal role in stem cell recruitment and homing through migration where the subsequent change in niche has been shown to alter these characteristics. The bone marrow mesenchymal stem c…

article 2015

Endometrial mesenchymal stem cells present with high regeneration and migration potential suggesting their involvement in endometrial monthly regeneration and development of endometrial disorders

2015

Endometrial stromal fibroblasts from women with polycystic ovary syndrome have impaired progesterone-mediated decidualization, aberrant cytokine profiles and promote enhanced immune cell migration in vitro.

Human reproduction (Oxford, England) ·doi:10.1093/humrep/dev055

Study questionDo endometrial stromal fibroblasts (eSF) in women with polycystic ovary syndrome (PCOS) (eSFpcos) exhibit altered estrogen and/or progesterone (P4) responses, which may explain some of the adverse reproductive outcomes and end…