Shang‐Hsun Yang
ORCID: 0000-0002-1601-3653
· 3 papers in corpus
lab-animal
2026
miR-196a reduces mutant Huntingtin aggregates by Rad23b-mediated degradation in Huntington's disease
BACKGROUND: Huntington's disease (HD) is a neurodegenerative disorder caused by abnormal expansions of poly-glutamine repeats in the mutant Huntingtin (mHTT). The expanded proteins form pathological aggregates to disrupt neuronal functions …
lab-animal
2015
STUDY HYPOTHESIS: DNA methylation is regulated by hypoxia in endometriosis. STUDY FINDING: Hypoxia causes global hypomethylation through AU-rich element binding factor 1 (AUF1)/microRNA-148a (miR-148a)-mediated destabilization of DNA methy…
lab-animal
2012
CONTEXT: Aberrant activation of MAPK has been implicated to play important roles in pathological processes of endometriosis. However, how MAPK are constitutively activated in endometriotic tissues remains largely unknown. microRNA are small…