Kagan D

No ORCID on file · 2 papers in corpus · active 2008-2010

Study types

  • other 2

Condition tags

  • endometriosis 2
other 2010
A long-acting tumor necrosis factor alpha-binding protein demonstrates activity in both in vitro and in vivo models of endometriosis
The Journal of pharmacology and experimental therapeutics ·doi:10.1124/jpet.110.166488

Endometriosis is characterized by the presence of elevated proinflammatory cytokines such as tumor necrosis factor (TNF) alpha in the peritoneal cavity. Blocking interaction of TNFalpha with its receptor by the addition of excess TNFalpha-b…

other 2008
Tumor necrosis factor-alpha regulates inflammatory and mesenchymal responses via mitogen-activated protein kinase kinase, p38, and nuclear factor kappaB in human endometriotic epithelial cells
Molecular pharmacology ·doi:10.1124/mol.107.042176

Tumor necrosis factor (TNF)-alpha is central to the endometriotic disease process. TNF-alpha receptor signaling regulates epithelial cell secretion of inflammation and invasion mediators. Because epithelial cells are a disease-inducing comp…