Zhang Y

To mark 5 years of Cell Genomics, we asked authors across China to reflect on their research and the field of genomics. Together, these voices reflect on their findings, publishing, belonging to a community, and what shape the field's next …

Endometriosis is a widespread gynecological disorder causing severe pain and infertility, with diagnosis currently relying on slow, costly, and risky laparoscopy. This highlights the critical need for non-invasive imaging diagnostics using …

This study aimed to investigate the pathogenic mechanisms of jaw cysts by screening for differentially expressed proteins in the tissues of patients with jaw cysts using proteomic techniques. Tissue samples were collected from 4 patients wi…

Postoperative alterations in peritoneal anatomical planes, unclosed mesenteric defects after reimplanted ureter may pose risk of internal hernia. This case report begins with a typical clinical case to present our team's diagnostic and ther…

BACKGROUND: Few studies comprehensively examined women's life-course reproductive patterns and the risk of dementia. This study aims to examine the association between women's reproductive life sequence and dementia, and to explore the pote…

PURPOSE: The prevalence of hyperuricemia has been increasing worldwide. Most studies have focused on the influences of hyperuricemia on kidney damage and cardiovascular disease. However, the impacts of hyperuricemia on the liver remain uncl…

Ectopic spleen (ES) is a rare complication of autologous transplant following spleen injury. Autopsy studies suggest that the true incidence rate could be as high as 67%, though only 5%-10% of patients require clinical intervention. This ca…

Advanced glycation end products (AGEs) are a group of compounds formed through non-enzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. AGEs can be generated in the body or introduced through dietary sources a…

We wished to ascertain if there is an association between neutrophil extracellular traps and endometriosis (EMS). We collected the lesional tissues and normal endometrium of 30 patients suffering from endometriosis. Samples were also taken …

Polycystic ovary syndrome is the primary cause of female infertility. Growing evidence suggests that dysregulation of amino acid metabolism plays a significant role in the onset and progression. However, the underlying mechanism remains unc…

BACKGROUND: Adenomyosis (AM) is a common benign gynecological disease, defined by the presence of endometrial glands and stroma deep within the myometrium, which is associated with hypertrophy and hyperplasia of the adjacent myometrium. It …

PURPOSE: To investigate the dynamic changes of serum Anti-Müllerian Hormone (AMH) and Inhibin B (INHB) during controlled ovarian hyperstimulation (COH) in patients with polycystic ovarian syndrome (PCOS) and analyze their correlation with C…

BACKGROUND: The burden of comorbidities in those with uterine fibroids compared to those without fibroids is understudied. We performed a phenome-wide association study to systematically assess the association between fibroids and other con…

BACKGROUND: The cervicovaginal microbiome-spanning from the vagina to endometrium-remains undercharacterized in endometriosis-associated infertility. Objective: To determine whether combined vaginal and cervical microbial profiles predict f…

PURPOSE: This study aims to create and validate a clinical prediction model to determine the optimal gonadotropin (Gn) starting dose in controlled ovarian stimulation (COS) protocols for normal ovarian response (NOR) patients undergoing the…

PURPOSE: The International Federation of Gynecology and Obstetric (FIGO) stage is critical to guiding the treatments of ovarian cancer (OC). We tried to develop a model to predict the FIGO stage of OC through machine learning algorithms wit…

Repeated implantation failure (RIF) presents a significant challenge to in vitro fertilization (IVF), and abnormalities in the endometrium often play a crucial role in RIF. To enhance and deepen our understanding of tissue context in the en…

BACKGROUND: A wealth of evidence indicates that dyslipidemia is associated with endothelial dysfunction, oxidative stress, and inflammation, each of which can impair reproductive function and lead to infertility. The Atherogenic Index of Pl…

BACKGROUND: Inflammation and high-density lipoprotein (HDL) metabolism are strongly linked to female infertility. The ratios of neutrophil-, lymphocyte-, platelet- and monocyte-to-HDL cholesterol (NHR, LHR, PHR, and MHR) are HDL-related inf…

OBJECTIVES: Tuberculosis (TB) is a common cause of infertility in humans, especially in regions with high TB prevalence. However, the impact of latent TB infection (LTBI) on pregnancy outcomes following assisted reproduction in patients wit…

BACKGROUND: Infertility in women of reproductive age is a major worldwide health problem. Oxidative stress, inflammatory responses, and dysregulation of lipid metabolism are among the factors that contribute to female infertility. The ratio…

BACKGROUND & OBJECTIVE: To assess the association of assisted reproductive technologies (ART) conception with postpartum hemorrhage (PPH) during the peripartum and postpartum periods. METHODS: Clinical records of 11,497 patients enrolled i…

BACKGROUND: Although the dietary inflammatory index (DII) plays a vital role in human health, the association between the DII and women's menopausal status is still unclear. The aim of this study was to investigate the associations of the e…

BACKGROUND: Previous studies have focused on the effects of ambient air pollutant levels on assisted reproduction. This research focused on the combined effects of lower concentrations of air pollutants and multiple environmental factors on…