Naoki Tomita

No ORCID on file · 2 papers in corpus · active 2010

Study types

  • other 2

Condition tags

  • endometriosis 2
other 2010
2-acylamino-4,6-diphenylpyridine derivatives as novel GPR54 antagonists with good brain exposure and in vivo efficacy for plasma LH level in male rats
Bioorganic & medicinal chemistry ·doi:10.1016/j.bmc.2010.05.061

GPR54 is a G protein-coupled receptor (GPCR) which was formerly an orphan receptor. Recent functional study of GPR54 revealed that the receptor plays an essential role to modulate sex-hormones including GnRH. Thus, antagonists of GPR54 are …

other 2010
Synthesis and structure-activity relationships of 2-acylamino-4,6-diphenylpyridine derivatives as novel antagonists of GPR54
Bioorganic & medicinal chemistry ·doi:10.1016/j.bmc.2010.04.036

GPR54 is a G protein-coupled receptor (GPCR) which was formerly an orphan receptor. Recent functional study of GPR54 revealed that the receptor has an essential role to modulate sex-hormones including GnRH. Though antagonists of GPR54 are e…