Diane M. Duffy — Endo Lab

article 2024

Prostaglandin E2 regulates the plasminogen activator pathway in human endometrial endothelial cells: a new in vitro model to investigate heavy menstrual bleeding

·doi:10.1016/j.xfss.2024.07.007

Objective To study the role of PGE2 in regulating plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) in human primary endometrial endothelial cells (HEECs) from women with normal menstrual bleeding (NMB) and he…

2019

Ovulation: Parallels With Inflammatory Processes.

Endocrine Reviews ·doi:10.1210/er.2018-00075

The midcycle surge of LH sets in motion interconnected networks of signaling cascades to bring about rupture of the follicle and release of the oocyte during ovulation. Many mediators of these LH-induced signaling cascades are associated wi…

2015

Novel contraceptive targets to inhibit ovulation: the prostaglandin E2 pathway.

Human Reproduction Update ·doi:10.1093/humupd/dmv026

BackgroundProstaglandin E2 (PGE2) is an essential intrafollicular regulator of ovulation. In contrast with the one-gene, one-protein concept for synthesis of peptide signaling molecules, production and metabolism of bioactive PGE2 requires …

article 2005

An Ovulatory Gonadotropin Stimulus Increases Cytosolic Phospholipase A2 Expression and Activity in Granulosa Cells of Primate Periovulatory Follicles

·doi:10.1210/jc.2005-0980

CONTEXT: Prostaglandins (PGs) produced within ovarian follicles in response to the ovulatory gonadotropin surge are essential for follicle rupture and oocyte release. Arachidonic acid, the common precursor for PG synthesis, is cleaved from …