Kennedy SR

ORCID: 0000-0002-4444-1145 · 3 papers in corpus · active 2018-2022
2022
Myometrial oxidative stress drives MED12 mutations in leiomyoma.
Cell & bioscience ·doi:10.1186/s13578-022-00852-0

BackgroundMore than 70% of leiomyomas (LM) harbor MED12 mutations, primarily in exon 2 at c.130-131(GG). The cause of MED12 mutations in myometrial cells remains largely unknown. We hypothesized that increased ROS promotes MED12 mutations i…

2019
Cancer-Associated Mutations but No Cancer: Insights into the Early Steps of Carcinogenesis and Implications for Early Cancer Detection.
Trends in cancer ·doi:10.1016/j.trecan.2019.07.007

Cancer is a disease of aging fueled by the accumulation of somatic mutations. While mutations in tumors are well characterized, little is known about the early mutational processes that initiate tumorigenesis. Recent advances in next-genera…

2018
Aging and the rise of somatic cancer-associated mutations in normal tissues.
PLoS genetics ·doi:10.1371/journal.pgen.1007108

DNA mutations are inevitable. Despite proficient DNA repair mechanisms, somatic cells accumulate mutations during development and aging, generating cells with different genotypes within the same individual, a phenomenon known as somatic mos…