Schindler K — Endo Lab

2022

Acentriolar spindle assembly in mammalian female meiosis and the consequences of its perturbations on human reproduction†.

Biology of reproduction ·doi:10.1093/biolre/ioab210

The purpose of meiosis is to generate developmentally competent, haploid gametes with the correct number of chromosomes. For reasons not completely understood, female meiosis is more prone to chromosome segregation errors than meiosis in ma…

2022

Predicting embryonic aneuploidy rate in IVF patients using whole-exome sequencing.

Human genetics ·doi:10.1007/s00439-022-02450-z

Infertility is a major reproductive health issue that affects about 12% of women of reproductive age in the United States. Aneuploidy in eggs accounts for a significant proportion of early miscarriage and in vitro fertilization failure. Rec…

2021

Human MLH1/3 variants causing aneuploidy, pregnancy loss, and premature reproductive aging.

Nature communications ·doi:10.1038/s41467-021-25028-1

Embryonic aneuploidy from mis-segregation of chromosomes during meiosis causes pregnancy loss. Proper disjunction of homologous chromosomes requires the mismatch repair (MMR) genes MLH1 and MLH3, essential in mice for fertility. Variants in…