Zhao Y

ObjectiveOur study aims to establish and validate a diagnostic scoring system for distinguishing malignant cystic ovarian tumors (MCOTs) from benign cystic ovarian tumors (BCOTs).MethodsThe study population was sourced from two independent …

BACKGROUND: Adenomyosis, a common gynecological disorder in women of reproductive age, is characterized by endometrial invasion into the myometrium, leading to uterine enlargement and smooth muscle hypertrophy. Typical clinical symptoms inc…

In the treatment of ulcerative colitis (UC), persistent inflammatory activity increases the risk of recurrence and poor prognosis. Probe-based confocal laser endomicroscopy (pCLE) can accurately assess the UC inflammation than conventional …

Testosterone is commonly measured using immunoassays in clinical practice; however, these methods are subject to analytical interference in both men and women. In women, due to physiologically lower testosterone levels, even modest elevatio…

Abstract Background: Ovarian sex cord-stromal tumors are rare neoplasms originating from the sex cords and stromal tissue of the ovary, with extraovarian occurrences being even rarer in clinical settings. In this report, we describe a case…

BACKGROUND: Endometriosis is a chronic inflammatory disorder affecting reproductive-aged women. The Dietary Inflammatory Index (DII), a measure of diet-related inflammation, has been implicated in various inflammatory diseases, but its role…

ObjectiveTo investigate the relationship between protein-rich foods, various nutritional supplements, and age of natural menopause and its symptoms.MethodsThis study was a large-scale cross-sectional survey. A multi-stage stratified random …

The aim of this study is to investigate the mechanism of action and correlation between transforming growth factor beta 1 (TGF-β1) and β-catenin in pelvic organ prolapse (POP). The study compared vaginal wall tissues from two groups: 20 pat…

Women's reproductive health plays a pivotal role in both longevity and the aging process. We conduct Mendelian randomization (MR) and observational analyses to investigate these relationships. Univariate MR analyses reveal that older age at…

BackgroundThe administration of exogenous gonadotropins (Gn) to elicit multi-follicular development for controlled ovarian stimulation (COS) represents a pivotal component of assisted reproductive technology (ART). Presently, the exogenous …

This study investigated differences in reproductive outcomes and vaginal microbiota profiles between two endometrial preparation protocols-letrozole (LE) combined with human menopausal gonadotropin (HMG) and hormone replacement therapy (HRT…

IN BRIEF: There is no ideal animal model of adenomyosis, which reflects the imperfect understanding of complex human pathogenesis. In this study, we successfully induced adenomyosis in a mouse model via sharp-blunt trauma, which more closel…

Yiming Zhao,1,2,* Xinyu Hu,1,* Chunyan Li,2 Jing Huang,3 Ke Guo,4 Qiong Pan,1 Zheng Yu2 1Department of Obstetrics and Gynecology, the Third Xiangya Hospital of Central South University, Changsha, People’s Republic of China; 2Human M…

PURPOSE: Endometriosis (EMS) is a chronic gynecological disorder with unclear pathogenesis. While the vaginal and gut microbiomes are known to influence EMS, few studies have analyzed both microbiomes integrally. This study aims to characte…

[This corrects the article DOI: 10.3389/fgene.2025.1614573.].

ObjectiveTo develop and validate a diagnostic nomogram model for predicting atypical endometrial hyperplasia (AEH) and endometrial carcinoma (EC) in women aged 40-60 years with abnormal uterine bleeding (AUB), incorporating detailed bleedin…

BackgroundInfertility has become a global health concern, especially as the aging population continues to grow. Previous studies suggest that gut microbiota plays a crucial role in female reproductive health. This study aimed to investigate…

Drug repositioning presents a compelling strategy to accelerate therapeutic development by uncovering new indications for existing compounds. However, current computational methods are often limited in their ability to integrate heterogeneo…

Hu sheep are renowned for their adaptation to high-temperature, humid environments and their high fecundity. Despite serving as the founder species for sheep breeding in China, the genetic mechanisms underlying these desirable traits and th…

Chengcheng Ren,1,* Yanan He,1,* Yunlong Zhao,2 Guangmei Zhang1 1Department of Gynecology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People’s Republic of China; 2Plastic Surgery Laser Center, T…

BACKGROUND: Endometriosis (EMs) is a benign gynecological disorder that exhibits several malignant characteristics, including proliferation and angiogenesis. N6-methyladenosine (m6A) modification plays a crucial role in regulating RNA splic…

BackgroundOverweight and obesity can induce an inflammatory milieu in the oocyte microenvironment and are closely associated with reduced assisted reproductive outcomes.ObjectiveHow are immune cells, cytokines and lipid profiles altered in …

IntroductionAlthough advanced paternal age (APA) is increasingly scrutinized in reproductive medicine, its independent impact on embryo development and clinical outcomes remains contentious, particularly when controlling for maternal age an…

BackgroundOverweight and obesity are link to impaired endometrial receptivity and decreased pregnancy success in frozen-thawed embryo transfer (FET) cycles. Depot gonadotropin-releasing hormone agonist (GnRH-a) pretreatment before hormone r…