Li S

Laparoscopic gynecological surgery, despite its minimally invasive nature, is frequently associated with significant postoperative pain, encompassing somatic, visceral, and referred components. This pain poses challenges to patient recovery…

PurposeThis study aimed to develop and validate a robust multicenter deep learning pipeline that integrates radiomic descriptors with deep feature embeddings to enable comprehensive ovarian tumor analysis from ultrasound imaging, encompassi…

BACKGROUND: Ovarian clear cell carcinoma (OCCC) is a rare histological subtype of ovarian cancer, often associated with endometrial lesions, and characterized by poor prognosis and a high propensity for recurrence and metastasis. This study…

BackgroundGynecologic neuroendocrine carcinomas (NECs) are rare, highly aggressive malignancies with early metastatic potential and limited evidence to guide optimal management across different primary sites.AimsTo characterize the clinicop…

BackgroundSpermidine is involved in a wide range of cellular processes, including mammalian oocyte development. Wheat germ is a natural source of polyamines and contains high concentrations of spermidine. However, no studies have evaluated …

Infertility is a global public health issue, and a favorable endometrial environment is essential for successful assisted reproductive treatment. Endometrial polyps (EM) and hydrosalpinx (HD) are common gynecological disorders impairing the…

ObjectiveTo investigate estrogen receptor gene 1 (ESR1) and estrogen-driven transcription in human endometrial stromal cells.DesignRNA sequencing (RNA-seq) and Cleavage Under Targets and Release Using Nuclease (Cut&Run) were performed on te…

Endometriosis (EMS) is a chronic condition primarily characterized by pain and infertility, significantly affecting the physical, mental, and emotional well-being of patients. The primary goal of EMS treatment is to improve patients' qualit…

Graphical abstractAbstractThe endometrium is the primary site of embryo implantation. Cellular senescence within the endometrium can be broadly categorised into normal cyclical senescence and pathological excessive senescence. Normal cyclic…

Endoplasmic reticulum (ER) stress is a key cellular mechanism that is important in the development of many diseases, including cancer. Since the discovery of the unfolded protein response (UPR), research has greatly improved our understandi…

With the rapid progression of urbanization and the widespread adoption of nocturnal work and lifestyle patterns, artificial light at night (ALAN) has emerged as a significant environmental factor impacting women's health. Current research s…

BackgroundUterine adenomatoid tumors (UATs) are rare benign mesothelial neoplasms with poorly characterized molecular features. Comprehensive genomic profiling of UATs remains limited.MethodsTargeted sequencing of 20 pathologically confirme…

ObjectiveThe study systematically examines the long-term trends in the global burden of Polycystic ovary syndrome (PCOS) across 204 countries and territories, with a specific focus on comparing pre-pandemic (1990-2019) and post-pandemic (20…

With women aged ≥50 years projected to reach 1.65 billion by 2050, gynecological and breast cancers impose an escalating postmenopausal burden. Whether menopausal timing independently influences cancer risk remains uncertain. We integrated …

Acute pancreatitis (AP) is a frequent inflammatory disorder with outcomes ranging from mild disease to severe forms marked by infection and organ failure. Gut microenvironment disruption and barrier dysfunction are increasingly recognized a…

BackgroundThe ovary is a vital and dynamic reproductive organ. Ovarian tissue cryopreservation (OTC) plays a vital role in preserving female fertility. However, the cellular subtypes most susceptible to cryoinjury and the molecular mechanis…

ImportanceTonsillectomy has long been scrutinized for its potential long-term impacts on health, with conflicting evidence linking it to increased risks of several diseases, such as cancer, psychiatric disorders, and immune dysfunctions.Obj…

In the whole laying cycle, the late laying phase is the longest segment, and it directly determines total egg production and influences the timing of culling. To investigate the mechanisms underlying the decline in egg-laying performance du…

The risk of placenta accreta spectrum (PAS) associated with in vitro fertilization and embryo transfer (IVF-ET) in the context of mid-trimester pregnancy loss remains unclear. This study aimed to investigate the impact of IVF-ET on the inci…

IntroductionUlcerative colitis (UC) is a lifelong, chronic inflammatory disorder, characterized by recurrent and diffuse inflammation of the rectal and colonic mucosa. Increasing evidence suggests that impaired mitophagy contributes to immu…

BackgroundSalpingitis is a leading cause of female infertility and ectopic pregnancy worldwide. Despite advances in reproductive medicine, its early diagnosis and effective prevention of long-term sequelae remain challenging due to its ofte…

BackgroundCervical clear cell adenocarcinoma (CCAC) and cervical endometrioid adenocarcinoma (CEAC) are rare and aggressive non-HPV-associated malignancies. Despite their histological similarities, these subtypes demonstrate distinct biolog…

Persistent organic pollutants (POPs) are a class of chemical substances with environmental persistence, bioaccumulation, and high toxicity, which are widely present in the environment and food chains. Prostate cancer (PCa) is a highly preva…