Liu B

Endometriosis, affecting approximately 10% of reproductive-aged women worldwide, is widely recognized as a chronic inflammatory disease. Inflammation-related genes (IRGs) play a crucial role in the occurrence and progression of various dise…

BACKGROUND: Effective individualized tools to predict cumulative live birth rates are lacking for patients with ovarian endometriomas undergoing In Vitro Fertilization or Intracytoplasmic Sperm Injection after ultrasound-guided ethanol scle…

Human endometrial receptivity is a critical determinant of pregnancy success; however, in vivo studies of its features and regulation are particularly challenging due to ethical restrictions. Recently, the development of human endometrial a…

BACKGROUND: Ovarian endometriomas impair ovarian reserve and fertility in women of reproductive age. Ethanol sclerotherapy is a fertility-preserving alternative to surgery. Nonetheless, predicting cumulative live birth rates after in vitro …

BACKGROUND: Cervical squamous cell carcinoma (CSCC) exhibits profound spatial heterogeneity in evolutionary trajectories across distinct tumour foci, yet the underlying mechanisms remain poorly understood. METHODS: In this study, we perfor…

Pelvic venous disorders (PeVD) are an underrecognized yet significant cause of chronic pelvic pain (CPP) in reproductive-aged women, characterized by venous reflux, obstruction, or both. This clinical opinion provides a practical overview o…

Endometriosis is a debilitating, estrogen-dependent gynecological disorder characterized by profound diagnostic delays due to clinical reliance on invasive laparoscopy. Developing noninvasive, point-of-care biomarker assessment remains a cr…

Serum and plasma are the most widely used matrices in metabolomics and human biomonitoring studies; however, the optimal matrix for integrated non-targeted analysis (NTA) workflows combining metabolomics and exposomics has not been systemat…

OBJECTIVE: This study aims to investigate the efficacy of novel embolic materials in the treatment of adenomyosis via partial embolization of uterine arteries. METHODS: From June 2023 to June 2025, we used gelatin sponge particles, liquid s…

RESEARCH QUESTION: Does pyruvate carboxylase drive the progression of endometriosis, and, if so, what is the underlying mechanism? DESIGN: The expression of pyruvate carboxylase in clinical endometrial specimens was examined via immunohist…

BACKGROUND: Endometriosis is an estrogen-driven, inflammatory disorder affecting ~10% of menstruators, causing severe pain. Current treatments that reduce estrogen or inflammation have inconsistent efficacy and poor tolerability. Therapies …

Adenomyosis (AM) is an estrogen-dependent gynecological disorder in which local steroid handling may contribute to clinical heterogeneity. To characterize estrogen metabolic features in AM, we used liquid chromatography-tandem mass spectrom…

Vitamin D has attracted increasing attention in male reproduction, male fertility, and sperm function, but its pharmacological relevance remains incompletely defined. This review synthesizes current evidence on the molecular mechanisms and …

High-throughput sequencing enables efficient processing of DNA and RNA samples in batches, but batch effects can obscure true biological signal. We propose using anticlustering as an automated method to assign samples to balanced batches, m…

High throughput sequencing is a powerful tool for processing large amounts of DNA and RNA samples in batches. Proper experimental design and statistical methods are required to mitigate systematic technical factors due to differences in bat…

BACKGROUND: The risk of preterm birth (PTB) is associated with maternal hyperglycemia but differs by combinations of abnormal oral glucose tolerance test (OGTT) values. However, the potential pathway by which maternal hyperglycemia affects …

Abstract Endometriosis, affecting approximately 10% of reproductive-aged women worldwide, is a typical chronic inflammatory disease. Inflammation-related genes (IRGs) play a crucial role in the occurrence and progression of various disease…

Decreased ovarian reserve (DOR) refers to the decreased ability of the ovaries to produce eggs and the low quality of the follicles, which may lead to abnormal menstruation and infertility. However, the role of circular RNAs (circRNAs) in D…

Endometriosis is an estrogen-dependent chronic inflammatory disease which causes dysmenorrhea, chronic pelvic pain, and infertility in women of childbearing age, significantly impacting their quality of life and physical and mental health. …

Single-cell technologies are expanding our understanding of endometriosis and adenomyosis, which are sister disorders of the uterine endometrium that contain similar complements of lesion cell types but in different locations-outside and in…

INTRODUCTION: Although advanced paternal age (APA) is increasingly scrutinized in reproductive medicine, its independent impact on embryo development and clinical outcomes remains contentious, particularly when controlling for maternal age …

Ageing of the endometrium is a critical factor that affects reproductive health, yet its intricate mechanisms remain poorly explored. In this study, we performed transcriptome profiling and experimental verification of endometrium and endom…

OBJECTIVE: To analyze the relationship and predictive value of Netrin-1 expression and ultrasonic blood flow parameters with the severity of cervical intraepithelial neoplasia (CIN). METHODS: A retrospective analysis was performed on 115 p…