Carol A. Lange — Endo Lab

other 2023

Navigating a plethora of progesterone receptors: Comments on the safety/risk of progesterone supplementation in women with a history of breast cancer or at high-risk for developing breast cancer

Steroids ·doi:10.1016/j.steroids.2023.109329

Progesterone and progestin agonists are potent steroid hormones. There are at least three major types of progesterone receptor (PR) families that interact with and respond to progesterone or progestin ligands. These receptors include ligand…

review 2015

Progesterone action in breast, uterine, and ovarian cancers

Journal of molecular endocrinology ·doi:10.1530/jme-14-0252

Progesterone and progesterone receptors (PRs) are essential for the development and cyclical regulation of hormone-responsive tissues including the breast and reproductive tract. Altered functions of PR isoforms contribute to the pathogenes…

review 2011

Progesterone receptor action: defining a role in breast cancer

Expert review of endocrinology & metabolism ·doi:10.1586/eem.11.25

The ovarian steroid hormones, estradiol and progesterone, and their nuclear receptors (estrogen receptor [ER] and progesterone receptor [PR]), are involved in breast cancer development. As ER-positive/PR-positive tumors progress, they are l…