Huang H

OBJECTIVE: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is primarily characterized by neonatal jaundice and acute/chronic hemolytic anemia. This study aimed to examine the influence of different G6PD genotypes on pregnancy and neonat…

BACKGROUND: CLEC5A (C-type lectin domain family 5 member A) is an innate immune receptor implicated in inflammatory signaling, contributing to hyperinflammatory responses in infections and sterile inflammation. However, CLEC5A dynamics in h…

BACKGROUND: Women of childbearing age (WCBA) in East Asia and Pacific (EAP) have experienced rapid epidemiological change, yet research focus and policy priorities often remain concentrated on maternal survival. We aimed to characterize thr…

Vasohibin-1 (VASH-1) is an endothelial protein that serves as a negative feedback regulator of angiogenesis. Through its microtubule carboxypeptidase activity, VASH-1 plays a key role in vascular homeostasis. While previous studies have inv…

OBJECTIVE: To evaluate the long-term therapeutic efficacy of uterine artery embolization (UAE) for adenomyosis and to identify independent prognostic factors associated with postoperative recurrence. METHODS: A total of 200 adenomyosis pati…

The clinical management of endometriosis encounters a significant obstacle: existing therapies inadequately address both the inhibition of ectopic lesion proliferation and the mitigation of the neuroinflammation associated with chronic pain…

Breast cancer prognosis and treatment outcomes are shaped by intricate interplay between tumor biology, systemic comorbidities, and patient-reported functional status. This paper introduces a framework to address critical gaps in precision …

BACKGROUND: Vitamin D deficiency is a global public health concern, and women of reproductive age represent a particularly vulnerable population. Accurate measurement of serum 25-hydroxyvitamin D [25(OH)D] is therefore essential for reliabl…

OBJECTIVE: To investigate the association between polycystic ovary syndrome (PCOS) and miscarriage risk and to explore the potential causal effect. METHODS: We conducted a retrospective cohort study of 445 women who conceived via in vitro …

BACKGROUND: Premature ovarian insufficiency (POI) is characterized by ovarian dysfunction that develops from diminished ovarian reserve (DOR). The exact aetiology of POI remains poorly understood. This study aims to elucidate the role of CK…

OBJECTIVE: To investigate the construction and clinical application value of Nomogram predictive model for recurrent spontaneous abortion (RSA) based on the expressions of MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1), miR…

BACKGROUND AND OBJECTIVES: Previous studies have reported there were associations between ovarian function and dietary factors, metabolic factors and gut microbiota. However, it is unclear whether causal associations exist. We aimed to expl…

STUDY QUESTION: What are the impacts of different male infertility factors on embryological, cumulative pregnancy and neonatal outcomes of IVF/ICSI cycles? SUMMARY ANSWER: Some severe male infertility factors, i.e. severe oligoasthenozoosp…

Total hysterectomy is a commonly performed gynecological procedure used to treat uterine pathologies. This study aimed to establish a total hysterectomy mouse model and investigate the effect of estradiol valerate on humoral immune function…

Ferredoxins (FDXs) are evolutionarily conserved iron-sulfur (Fe-S) proteins that serve as master regulators of mitochondrial redox homeostasis, governing critical processes including electron transfer, energy metabolism, Fe-S cluster biogen…

Infectious diseases, such as sexually transmitted infections (STIs) and maternal sepsis, are major contributors to female infertility, creating a substantial burden on women of reproductive age. Based on Global Burden of Disease (GBD) 2021,…

BACKGROUND: Uterine fibroids(UF), while histologically benign, constitute a pervasive yet inequitable epidemiological phenomenon characterized by disproportionately distributed morbidity burdens that correlate asymmetrically with regional d…

BACKGROUND: Surgery is the primary treatment for Endometrial Stromal Sarcoma (ESS), however, a substantial proportion of patients with ESS experience recurrence or metastasis. Currently, surgery and local ablation are the main treatments fo…

Atherosclerosis is a leading cause of cardiovascular diseases, causing significant morbidity and mortality. This review article examines the role of lactate and lactylation in atherosclerosis, a chronic inflammatory disease closely linked t…

BACKGROUND: The prognosis of patients with gastric cancer with peritoneal metastasis (GCPM) is exceedingly poor. This study evaluated the efficacy and safety of hyperthermic intraperitoneal chemotherapy (HIPEC) with paclitaxel combined with…

AIM: Endometriosis is characterized by immune evasion and progressive inflammation. This study aimed to identify key genes related to immune and inflammation in endometriosis. METHODS: Differentially expressed genes between patients with a…

BACKGROUND: Palmitoylation, a post-translational lipid modification, has garnered increasing attention for its role in inflammatory processes and tumorigenesis. Emerging evidence suggests a potential association between palmitoylation and i…

BACKGROUND: Overweight and obesity can induce an inflammatory milieu in the oocyte microenvironment and are closely associated with reduced assisted reproductive outcomes. OBJECTIVE: How are immune cells, cytokines and lipid profiles alter…

BACKGROUND: To investigate whether endometriosis is associated with the risk of incident nonalcoholic fatty liver disease (NAFLD). METHODS: Data were retrieved from Nurses' Health Study II with participants followed up from 1995 to 2017. A…