Clarke CH

No ORCID on file · 2 papers in corpus · active 2011-2016
2016
Validation of a Biomarker Panel and Longitudinal Biomarker Performance for Early Detection of Ovarian Cancer.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society ·doi:10.1097/igc.0000000000000737

ObjectivesLongitudinal multimarker combinations have the potential to improve sensitivity while maintaining the high specificity required for the early detection of ovarian cancer. The use of multiple markers to improve sensitivity over can…

2011
Proteomic biomarkers apolipoprotein A1, truncated transthyretin and connective tissue activating protein III enhance the sensitivity of CA125 for detecting early stage epithelial ovarian cancer.
Gynecologic Oncology ·doi:10.1016/j.ygyno.2011.06.002

ObjectiveThe low prevalence of ovarian cancer demands both high sensitivity (>75%) and specificity (99.6%) to achieve a positive predictive value of 10% for successful early detection. Utilizing a two stage strategy where serum marker(s) pr…