David Kagan

No ORCID on file · 6 papers in corpus · active 2006-2010

Study types

  • article 4
  • other 2

Condition tags

  • endometriosis 5
  • chronic_pelvic_pain 1
other 2010
A long-acting tumor necrosis factor alpha-binding protein demonstrates activity in both in vitro and in vivo models of endometriosis
The Journal of pharmacology and experimental therapeutics ·doi:10.1124/jpet.110.166488

Endometriosis is characterized by the presence of elevated proinflammatory cytokines such as tumor necrosis factor (TNF) alpha in the peritoneal cavity. Blocking interaction of TNFalpha with its receptor by the addition of excess TNFalpha-b…

article 2010
A Long-Acting Tumor Necrosis Factor -Binding Protein Demonstrates Activity in Both In Vitro and In Vivo Models

Endometriosis is characterized by the presence of elevated proinflammatory cytokines such as tumor necrosis factor (TNF) in the peritoneal cavity. Blocking interaction of TNF with its receptor by the addition of excess TNF-binding protein (…

article 2008
Interruption of Inflammatory Pathways with JNK Inhibitors Induces Regression of Human Endometriotic Lesions and Restores Progesterone Receptor Sensitivity in Endometrium and Lesions.
·doi:10.1093/biolreprod/78.s1.113b

Endometriosis is one of the most common causes of chronic pelvic pain, which affects over 70 million adult and adolescent women worldwide. The pathophysiology of endometriosis involves endocrine, inflammatory and angiogenic components and t…

article 2008
TNF-Binding Protein Complex Inhibits TNF-α-Mediated Effects in Human Endometriotic Cell Line.
·doi:10.1093/biolreprod/78.s1.67b

Endometriosis is characterized by the presence of elevated proinflammatory cytokines like TNFα in the peritoneal cavity. Inhibition of TNFα by TNF binding protein-1 (TBP-1), the soluble form of TNFα receptor-1, was effective in animal model…

other 2008
Tumor necrosis factor-alpha regulates inflammatory and mesenchymal responses via mitogen-activated protein kinase kinase, p38, and nuclear factor kappaB in human endometriotic epithelial cells
Molecular pharmacology ·doi:10.1124/mol.107.042176

Tumor necrosis factor (TNF)-alpha is central to the endometriotic disease process. TNF-alpha receptor signaling regulates epithelial cell secretion of inflammation and invasion mediators. Because epithelial cells are a disease-inducing comp…

article 2006
O-75
·doi:10.1016/j.fertnstert.2006.07.089