De Siena G

No ORCID on file · 3 papers in corpus · active 2024-2025

Study types

  • other 1
  • preprint 1

Condition tags

  • endometriosis 2
2025
Targeting prostaglandin E2 receptor 2 in Schwann cells inhibits inflammatory pain but not inflammation.
Nature communications ·doi:10.1038/s41467-025-63782-8

Analgesia by non-steroidal anti-inflammatory drugs (NSAIDs) is ascribed to inhibition of prostaglandin (PG) biosynthesis and ensuing inflammation. However, NSAIDs have life-threatening side effects, and inhibition of inflammation delays pai…

other 2024
Schwann cell C5aR1 co-opts inflammasome NLRP1 to sustain pain in a mouse model of endometriosis
Nature communications ·doi:10.1038/s41467-024-54486-6

Over 60% of women with endometriosis experience abdominopelvic pain and broader pain manifestations, including chronic back pain, fibromyalgia, chronic fatigue, vulvodynia, and migraine. Although the imbalance of proinflammatory mediators, …

preprint 2024
Schwann Cell C5aR1 co-opts Inflammasome NLRP1 to Sustain Pain in a Mouse Model of Endometriosis
·doi:10.21203/rs.3.rs-4045626/v1

Abstract Over 60% of women with endometriosis experience abdominopelvic pain alongside pain in other areas of the body, such as chronic back pain, fibromyalgia and chronic fatigue, vulvodynia, and migraine. Although the imbalance of proinf…