Auchus RJ

No ORCID on file · 4 papers in corpus · active 2007-2019

Study types

  • article 1

Condition tags

  • endometriosis 1
2019
Structural and Functional Biology of Aldo-Keto Reductase Steroid-Transforming Enzymes.
Endocrine reviews ·doi:10.1210/er.2018-00089

Aldo-keto reductases (AKRs) are monomeric NAD(P)(H)-dependent oxidoreductases that play pivotal roles in the biosynthesis and metabolism of steroids in humans. AKR1C enzymes acting as 3-ketosteroid, 17-ketosteroid, and 20-ketosteroid reduct…

2018
Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society Clinical Practice Guideline.
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2018-01865

ObjectiveTo update the congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency clinical practice guideline published by the Endocrine Society in 2010.ConclusionsThe writing committee presents updated best practice guidelines…

article 2008
Androstenedione Up-Regulation of Endometrial Aromatase Expression via Local Conversion to Estrogen: Potential Relevance to the Pathogenesis of Endometriosis
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2008-0248

CONTEXT: Up-regulation of aromatase expression in endometrial cells disseminated into the peritoneal cavity may enhance their survival via local estrogen synthesis, which may lead to endometriosis. The factors that mediate induction of arom…

2007
Variable phenotypes associated with aromatase (CYP19) insufficiency in humans.
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2006-1181

ContextThe P450 enzyme aromatase (CYP19) plays a crucial role in the endocrine and paracrine biosynthesis of estrogens from androgens in many diverse estrogen-responsive tissues. Complete aromatase deficiency has been reported in a small nu…