Paul Wieringa

In this study, a cell-mediated degradable alginate hydrogel system for organoid culture and amenable to biofabrication technologies is presented. Norbornene-functionalized alginate is crosslinked with a di-thiolated peptide sequence cleavab…

Abstract Functional humanized in vitro nerve models are coveted as an alternative to animal models due to their ease of access, lower cost, clinical relevance and no need for recurrent animal sacrifice. To this end, we developed a sensory n…

Nerves and blood vessels (BVs) establish extensive arborized networks to innervate tissues and deliver oxygen/metabolic support. Developmental cues direct the formation of these intricate and often overlapping patterns, which reflect close …