Kurt J. Sales — Endo Lab

2011

A role for lipoxin A₄ as an anti-inflammatory mediator in the human endometrium.

Reproduction (Cambridge, England) ·doi:10.1530/rep-11-0021

Lipoxin A(4) is a lipid mediator that elicits anti-inflammatory and pro-resolution actions via its receptor, formyl peptide receptor 2 (FPR2/ALX). In this study, we aimed to investigate the expression and potential role of lipoxin A(4) and …

2010

EP2 receptor mediated cAMP release is augmented by PGF 2 alpha activation of the FP receptor via the calcium-calmodulin pathway.

Cellular signalling ·doi:10.1016/j.cellsig.2009.09.012

Prostaglandins exert their effects on target cells by coupling to specific G protein-coupled receptors (GPCRs) that are often co-expressed in the same cells and use alternate and in some cases opposing intracellular signaling pathways. This…

2010

Interleukin-11 in endometrial adenocarcinoma is regulated by prostaglandin F2alpha-F-prostanoid receptor interaction via the calcium-calcineurin-nuclear factor of activated T cells pathway and negatively regulated by the regulator of calcineurin-1.

The American Journal of Pathology ·doi:10.2353/ajpath.2010.090403

Interleukin-11 (IL-11) up-regulates the proliferative and invasive capacity of many cancers. Coexpression of glycoprotein 130 (GP130) and IL-11 receptor alpha (IL-11Ralpha) is necessary for high-affinity binding of IL-11 to IL-11Ralpha. Thi…

2009

Prostaglandin F(2alpha)-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcineurin-NFAT pathway.

Biochimica et biophysica acta ·doi:10.1016/j.bbamcr.2009.09.018

Pro-inflammatory mediators, like prostaglandin (PG) and chemokines, promote tumourigenesis by enhancing cell proliferation, migration of immune cells and recruitment of blood vessels. Recently we showed elevated expression of the chemokine …

2008

F-prostanoid receptor alters adhesion, morphology and migration of endometrial adenocarcinoma cells.

Oncogene ·doi:10.1038/sj.onc.1210883

Cellular adhesion to extracellular matrix is a central phenomenon for the maintenance of tissue integrity and cellular movement. Collectively, these processes are regulated by a fine-tuned balance between the formation and loosening of adhe…

review 2006

Prostaglandin receptors are mediators of vascular function in endometrial pathologies

Molecular and cellular endocrinology ·doi:10.1016/j.mce.2006.03.025

Prostaglandins are bioactive lipids produced from arachidonic acid by cyclooxygenase enzymes and specific terminal prostanoid synthase enzymes. Following biosynthesis, prostaglandins exert an autocrine/paracrine function by coupling to spec…

2005

A novel angiogenic role for prostaglandin F2alpha-FP receptor interaction in human endometrial adenocarcinomas.

Cancer research ·doi:10.1158/0008-5472.can-05-0101

Prostaglandins have been implicated in several neovascular diseases. In the present study, we found elevated FP receptor and vascular endothelial growth factor (VEGF) expression colocalized in glandular epithelial and vascular cells lining …

article 2004

Prostaglandin receptor signalling and function in human endometrial pathology

Trends in endocrinology and metabolism: TEM ·doi:10.1016/j.tem.2004.08.006

Prostaglandins are bioactive lipids that exert an autocrine or paracrine function by binding to specific G-protein-coupled receptors (GPCRs) to activate intracellular signalling and gene transcription. Prostaglandins are key regulators of r…

review 2003

Cyclooxygenase enzymes and prostaglandins in pathology of the endometrium

Reproduction (Cambridge, England) ·doi:10.1530/rep.0.1260559

Prostaglandins are bioactive lipids produced from arachidonic acid by cyclooxygenase (COX) enzymes and specific terminal prostanoid synthase enzymes. After biosynthesis, prostaglandins exert an autocrine-paracrine function by coupling to sp…