Guo Y

BACKGROUND: This study aimed to investigate the role of low-density lipoprotein cholesterol as a key parameter in improving pregnancy outcomes after assisted reproductive technology treatments in women with diabetes mellitus. OBJECTIVE: To…

INTRODUCTION AND AIMS: Oral squamous cell carcinoma (OSCC) is a common malignant tumour of the head and neck region. In recent years, the relationship between pyroptosis and tumours has received increasing attention. However, its regulatory…

PURPOSE: This study aimed to construct a simple nomogram model to predict the benign or malignant nature of ovarian masses. METHODS: A total of 794 patients with ovarian masses from two independent medical centers between 2017 and 2024 wer…

[This corrects the article DOI: 10.1016/j.pscia.2026.100109.].

Adult endometrial glands undergo cyclic regeneration and development during the menstrual cycle. Their secretions are vital for endometrial functions and early pregnancy, yet the mechanisms controlling gland development are not well underst…

BACKGROUND: Mast cells (MCs) are pivotal immune cells. Beyond soluble mediators, mast cell-derived extracellular vesicles (MC-EVs) are crucial for intercellular communication. MC-EV heterogeneity, influenced by cellular activation and micro…

OBJECTIVE: The study systematically examines the long-term trends in the global burden of Polycystic ovary syndrome (PCOS) across 204 countries and territories, with a specific focus on comparing pre-pandemic (1990-2019) and post-pandemic (…

Lactic acid modification of histones represents an emerging post-translational modification that establishes a critical link between cellular metabolic reprogramming and epigenetic regulation through the covalent binding of lactic acid to h…

BACKGROUND: Endometrial thickness (EMT) is widely monitored in assisted reproductive technology as a marker of implantation potential, yet its precise association with pregnancy and perinatal outcomes in frozen embryo transfer (FET) cycles …

INTRODUCTION: Adenomyosis is an enigmatic disease with estrogen dependence, and the exact pathogenic mechanisms remain confusing. Limited evidence points out the presence of gut flora changes in adenomyosis. However, evidence on how adenomy…

BACKGROUND: Chronic pain resulting from postoperative adhesions represents a significant clinical concern due to its substantial impact on patient quality of life; however, optimal therapeutic management remains contentious. This systematic…

Recent studies have highlighted the crucial role of mechanical properties in the ovarian microenvironment for ovarian function. However, the mechanisms that cause ovarian matrix stiffening during aging remain incompletely understood. Here w…

BACKGROUND: Age-related diminished ovarian reserve (DOR) exhibits marked significant individual variation. Some women of advanced age with normal ovarian reserve (NOR) achieve better reproductive outcomes than age-matched DOR patients. OBJE…

BACKGROUND: Irregular sleep and eating patterns in modern lifestyles may disrupt reproductive rhythms, thereby impairing reproductive function in adult women. In livestock production, improper management may disturb livestock eating and act…

Novel brominated flame retardants (NBFRs), including 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE), are emerging endocrine-disrupting chemicals, though their direct effects on female gamete maturation remain insufficiently characterized. In …

The Ovarian-Adnexal Reporting and Data System (O-RADS), developed by the American College of Radiology (ACR), provides a standardized, evidence-based framework for risk stratification and management of ovarian and adnexal lesions. The O-RAD…

Clinical application of mesenchymal stem cells for endometrial repair has been hampered by variability in cell quality, large-scale production, and uncertainty regarding the optimal delivery route. In this study, we investigated the therape…

From a pathophysiological standpoint, adolescence is the critical period for the establishment, stabilization, and maturation of the hypothalamic-pituitary-ovarian (HPO) axis. In the 1-2 years following menarche, coinciding with the establi…

In brief: We present the first single-cell transcriptomic atlas of follicular fluid from an ovarian endometrioma (OMA) patient, revealing a novel TCR+ macrophage subtype, aberrant granulosa cell developmental trajectories, immune dysregulat…

BACKGROUND: Ovarian cancer, the third most prevalent gynecological malignancy, is frequently diagnosed at an advanced stage owing to its asymptomatic early progression. Despite the application of conventional therapies, clinical management …

ABSTRACT: This retrospective study investigated factors associated with abnormal endometrial peristaltic waves (EPWs) and evaluated the impact of Atosiban intervention on clinical outcomes in frozen-thawed embryo transfer (FET) cycles. A to…

Infertility remains a global challenge, with female factors accounting for the majority of cases. Endometrial receptivity (ER), the ability of the endometrium to accept and support embryo implantation, is a critical determinant of successfu…

BACKGROUND: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) have been shown to disrupt normal follicular development and ovulation. However, it is unknown which specific PFAS in follicular fluid negatively impact oocyte development and…

BACKGROUND: Infertility in women of reproductive age is a major worldwide health problem. Oxidative stress, inflammatory responses, and dysregulation of lipid metabolism are among the factors that contribute to female infertility. The ratio…