Håkon Håkonarson

2023

Genetic effects on the timing of parturition and links to fetal birth weight.

Nature genetics ·doi:10.1038/s41588-023-01343-9

The timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic basis remains largely unresolved. We present a maternal genome-wide meta-analysis of gestational duration (n = 195,555), identifying 22 associate…

other 2023

Inference of Causal Relationships Between Genetic Risk Factors for Cardiometabolic Phenotypes and Female-Specific Health Conditions

Journal of the American Heart Association ·doi:10.1161/JAHA.121.026561

Background Cardiometabolic diseases are highly comorbid, but their relationship with female-specific or overwhelmingly female-predominant health conditions (breast cancer, endometriosis, pregnancy complications) is understudied. This study …

2022

Inference of causal relationships based on the genetics of cardiometabolic traits and conditions unique to females in >50,000 participants

·doi:10.1101/2022.02.02.22269844

Background Cardiometabolic diseases are highly comorbid and associated with poor health outcomes. However, the investigation of the relationship between the genetic predisposition to cardiometabolic diseases with the risk of conditions uniq…

2022

Inference of causal relationships between genetic risk factors for cardiometabolic phenotypes and female-specific health conditions

·doi:10.21203/rs.3.rs-1386628/v1

Abstract Cardiometabolic diseases are highly comorbid, but their relationship with female-specific health conditions (breast cancer, endometriosis, pregnancy complications) is understudied. Using electronic health record data from 71,008 a…

2021

Large trans-ethnic meta-analysis identifies AKR1C4 as a novel gene associated with age at menarche.

Human reproduction (Oxford, England) ·doi:10.1093/humrep/deab086

Study questionDoes the expansion of genome-wide association studies (GWAS) to a broader range of ancestries improve the ability to identify and generalise variants associated with age at menarche (AAM) in European populations to a wider ran…

2019

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Nature genetics ·doi:10.1038/s41588-019-0447-2

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

2019

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration.

Nature communications ·doi:10.1038/s41467-019-11881-8

The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm birth in 84,689 in…

2018

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Nature genetics ·doi:10.1038/s41588-017-0011-x

Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal gene…

article 2016

Copy number variation analysis reveals additional variants contributing to endometriosis development

Journal of assisted reproduction and genetics ·doi:10.1007/s10815-016-0822-1

PurposeEndometriosis is a gynecological disease influenced by multiple genetic and environmental factors. The aim of the current study was to use SNP-array technology to identify genomic aberrations that may possibly contribute to the devel…

2016

Genome-wide associations for birth weight and correlations with adult disease.

Nature ·doi:10.1038/nature19806

Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and cardiovascular dis…