McDonnell DP

No ORCID on file · 9 papers in corpus · active 1994-2025

Study types

  • other 2
  • review 2

Condition tags

  • endometriosis 4
2025
Targeting androgen receptor signaling to enhance cancer immunotherapy.
Trends in pharmacological sciences ·doi:10.1016/j.tips.2025.11.003

Men experience higher cancer incidence and mortality than women, and accumulating evidence implicates androgen receptor (AR) signaling as a key biological driver of these sex-based disparities. AR signaling can suppress adaptive anticancer …

2014
From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs).
Steroids ·doi:10.1016/j.steroids.2014.07.013

Our understanding of the molecular mechanisms underlying the pharmacological actions of estrogen receptor (ER) ligands has evolved considerably in recent years. Much of this knowledge has come from a detailed dissection of the mechanism(s) …

2010
Mechanisms of progesterone receptor inhibition of inflammatory responses in cellular models of breast cancer.
Molecular endocrinology (Baltimore, Md.) ·doi:10.1210/me.2010-0289

Both pro- and antimitogenic activities have been ascribed to progesterone receptor (PR) agonists and antagonists in breast cancer cells; however, the transcriptional responses that underlie these paradoxical functions are not apparent. Usin…

2010
Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators.
Molecular endocrinology (Baltimore, Md.) ·doi:10.1210/me.2009-0339

Selective estrogen receptor modulators (SERMs), such as tamoxifen (TAM), have been used extensively for the treatment and prevention of breast cancer and other pathologies associated with aberrant estrogen receptor (ER) signaling. These com…

other 2009
Characterization of antiestrogenic activity of the Chinese herb, prunella vulgaris, using in vitro and in vivo (Mouse Xenograft) models
Biology of reproduction ·doi:10.1095/biolreprod.107.065375

Prunella vulgaris (PV), a commonly used Chinese herb, also known as Self-heal, has a wide range of reported medicinal activities. By screening multiple herbs using the endometrial cancer cell line, ECC-1, and an alkaline phosphatase detecti…

review 1995
Definition of the critical cellular components which distinguish between hormone and antihormone activated progesterone receptor
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/0960-0760(95)00095-h

The steroid hormone progesterone is a key modulator of the cellular processes associated with the maintenance and development of female reproductive function. The biological activity of this hormone is mediated by specific nuclear receptors…

other 1995
Unraveling the human progesterone receptor signal transduction pathway Insights into antiprogestin action
Trends in endocrinology and metabolism: TEM ·doi:10.1016/1043-2760(95)00065-p

The steroid hormone progesterone is a key modulator of the cellular processes that are required for the development and maintenance of reproductive function. Produced primarily by ovarian granulosa cells, it mediates its biological activity…

review 1994
Definition of the cellular mechanisms which distinguish between hormone and antihormone activated steroid receptors
Seminars in cancer biology

Steroid hormones are key regulatory molecules required for the coordinated regulation of the events associated with growth, differentiation and maintenance of cellular homeostasis. A large number of clinical abnormalities have been shown to…

1994
The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells.
Molecular and cellular biology ·doi:10.1128/mcb.14.12.8356-8364.1994

The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B). In most cell contexts, hPR-B functions as a transcriptional activator of progesterone-responsive genes, whereas …