José Reis

Background: Endometriosis, believed by many to be rooted in immunology, is a chronic disease. Upregulation of programmed cell death protein 1 (PD-1) in immune cells may compromise their defensive function, a mechanism demonstrated in the co…

Endometriosis, a debilitating condition, affects one in ten women of reproductive age. Its pathophysiology remains unclear, though deficiencies in immune surveillance are thought to create an environment conducive to the evasion of ectopic …

PROBLEM: Endometriosis is a prevalent chronic gynecological disease linked to immune dysfunction. The protein T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) plays a crucial role in immune system balance. Malfunction of …

Endometriosis is a chronic inflammatory disorder, characterized by the presence of endometrial cells outside the uterine cavity. An increasing number of studies correlate the immune system with endometriosis, particularly NK receptors (NKR)…

Endometriosis is a benign chronic disease which can have different degrees of severity and can potentially affect any organ. Intestinal endometriosis occurs in 3%â€"37% of the cases, being more frequent in the rectosigmoid transition. Trans…

We present the case of a 45-year-old woman who was a smoker (15 pack-years) with no relevant past medical history. She had her menarche at 11 years old with regular cycles and was on oral contraception for >20 years. Can you diagnose this r…

Overview and aims: This article summarises the Portuguese endometriosis consensus elaborated in order to adapt to our population the consensus documents published in the literature. Endorsed by the Portuguese Society of Gynaecology, we esta…

Overview and aims: Deep endometriosis is defined as the presence of infiltrating lesions more than 5mm deep to the peritoneum and it corresponds to 5-10% of all endometriotic lesions. Laparoscopy is considered the gold standard for the diag…