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AbstractAcute pancreatitis (AP) is a disease characterized by an acute inflammatory phase followed by a convalescent phase. Diabetes mellitus (DM) was historically felt to be a transient phenomenon related to acute inflammation; however, it…
ObjectivesTotal pancreatectomy with islet autotransplantation (TPIAT) is a surgical option for refractory chronic pancreatitis-related pain. Despite the known clinical implications of TPIAT, the molecular effects remain poorly investigated.…
Chronic pancreatitis (CP) is considered an irreversible fibroinflammatory pancreatic disease. Despite numerous animal model studies, questions remain about local immune characteristics in human CP. We profiled pancreatic immune cell charact…
ObjectiveLittle data exist describing the change over time in islet function and glycemic control in patients with chronic pancreatitis (CP).MethodsIn 325 CP patients who underwent 2 mixed meal tolerance tests and/or glycated hemoglobin (Hb…