Jianjun Zhou

No ORCID on file · 14 papers in corpus
other 2026
Glycolytic reprogramming and MYH10 K1520 lactylation mediate eutopic endometrial collagen I deposition driven by PKM2-packaged ectopic endometrial extracellular vesicles
Molecular human reproduction ·doi:10.1093/molehr/gaag028

Endometriosis (EMs) is characterized by ectopic lesions that disrupt endometrial decidualization, a process frequently accompanied by aberrant collagen deposition and closely linked to clinical infertility. Extracellular vesicles (EVs) are …

other 2025
Extracellular vesicle-packaged PKM2 from endometriotic stromal cells promotes endometrial collagen I deposition by inhibiting autophagy in endometriosis
Cellular signalling ·doi:10.1016/j.cellsig.2024.111523

Aberrant endometrial collagen I deposition during the implantation window impairs endometrial stromal cell (ESC) decidualization, which may contribute to lower pregnancy rate in endometriosis (EMs) patients with in vitro fertilization (IVF)…

2025
Transplantation of UC-MSCs in ovary improves ovarian function and intermediate outcomes in IVF/ICSI cycles of POI patients: a clinical cohort study.
Stem cell research & therapy ·doi:10.1186/s13287-025-04680-0

BackgroundThis study aimed to evaluate the clinical outcomes of umbilical cord mesenchymal stem cell (UC-MSC) transplantation on ovarian function in women with premature ovarian insufficiency (POI), and its potential to improve in vitro fer…

article 2024
Ectopic endometrial stromal cell-derived extracellular vesicles encapsulating microRNA-25-3p induce endometrial collagen I deposition impairing decidualization in endometriosis
Molecular human reproduction ·doi:10.1093/molehr/gaae042

Endometrial collagen I undergoes dynamic degradation and remodelling in response to endometrial stromal cell (ESC) decidualization and embryo implantation. However, excessive collagen I deposition in the endometrium during the implantation …

preprint 2023
Endometriotic Stromal Cell-Derived Exosomal miR-25-3p Induces Endometrial Collagen Ⅰ Deposition Impairing Decidualization And Embryo Implantation via Targeting PTEN in Endometriosis
·doi:10.2139/ssrn.4325256
2023
Perinatal outcomes of singletons following double vitrification-warming procedures: a retrospective study using propensity score analysis.
BMC pregnancy and childbirth ·doi:10.1186/s12884-023-05369-z

BackgroundAlthough repeated cryopreservation is an occasional occurrence, the effect on perinatal outcomes is unclear. Therefore, the aim of this study was to evaluate the perinatal outcomes of singletons after embryo re-cryopreservation.Me…

other 2023
Study of T2 mapping in quantifying and discriminating uterine lesions under different magnetic field strengths: 1.5 T vs. 3.0 T
BMC medical imaging ·doi:10.1186/s12880-022-00960-w

BACKGROUND: MRI is the best imaging tool for the evaluation of uterine tumors, but conventional MRI diagnosis results rely on radiologists and contrast agents (if needed). As a new objective, reproducible and contrast-agent free quantificat…

2023
Targeting CD301+ macrophages inhibits endometrial fibrosis and improves pregnancy outcome.
EMBO molecular medicine ·doi:10.15252/emmm.202317601

Macrophages are a key and heterogeneous cell population involved in endometrial repair and regeneration during the menstrual cycle, but their role in the development of intrauterine adhesion (IUA) and sequential endometrial fibrosis remains…

2019
Influence of surgical evacuation on pregnancy outcomes of subsequent embryo transfer cycle following miscarriage in an initial IVF cycle: a retrospective cohort study.
BMC pregnancy and childbirth ·doi:10.1186/s12884-019-2543-9

BackgroundIt is still uncertain whether surgical evacuation adversely affects subsequent embryo transfer. The present study aims to assess the influence of surgical evacuation on the pregnancy outcomes of subsequent embryo transfer cycle fo…

article 2018
Decreased Endometrial IL-10 Impairs Endometrial Receptivity by Downregulating HOXA10 Expression in Women with Adenomyosis
BioMed research international ·doi:10.1155/2018/2549789

OBJECTIVE: The aim of this study was to investigate the potential role of IL-10 in regulating the receptivity marker HOXA10 in the endometrium of women with adenomyosis. METHODS: The expression levels of IL-10, HOXA-10, STAT3, and p-STAT3 i…

2017
Activating transcription factor 3 promotes embryo attachment via up-regulation of leukemia inhibitory factor in vitro.
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-017-0260-7

BackgroundA receptive endometrium is essential for maternal-embryonic molecular communication during implantation. However, the specific molecular regulatory mechanisms of the endometrial capacity remain poorly understood. Here, we examined…

2017
Enhanced HOXA10 sumoylation inhibits embryo implantation in women with recurrent implantation failure.
Cell death discovery ·doi:10.1038/cddiscovery.2017.57

HOXA10 has emerged as an important molecular marker of endometrial receptivity. Recurrent implantation failure (RIF) after in vitro fertilization-embryo transplantation (IVF-ET) treatment is associated with impaired endometrial receptivity,…

2017
Increased Krüppel-like factor 12 in recurrent implantation failure impairs endometrial decidualization by repressing Nur77 expression.
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-017-0243-8

BackgroundDecidualization is a prerequisite for successful implantation and the establishment of pregnancy. A critical role of impaired decidualization in subfertility has been established. In human endometrial stromal cells (hESCs), Krüppe…

article 2017
[Repeated superovulation induction after failure in previous IVF-ET cycles with the ultra-long protocol: Analysis of outcomes of clinical pregnancy].
Zhonghua nan ke xue = National journal of andrology

OBJECTIVE: To analyze the clinical outcomes of repeated superovulation induction in patients with adenomyosis or moderate to severe pelvic endometriosis after failure in previous IVF-ET cycles with the ultra-long protocol. METHODS: We retro…