Alistair Williams

ORCID: 0000-0002-7085-4525 · 24 papers in corpus
2023
Ulipristal acetate versus levonorgestrel-releasing intrauterine system for heavy menstrual bleeding: the UCON randomised controlled trial and mechanism of action study

BackgroundHeavy menstrual bleeding affects one in four women and negatively impacts quality of life. The levonorgestrel-releasing intrauterine system is an effective long-term treatment but is discontinued by many due to unpredictable bleed…

article 2021
The endometrial response to modulation of ligand-progesterone receptor pathways is reversible
Fertility and sterility ·doi:10.1016/j.fertnstert.2021.02.008

ObjectiveTo study the impact of the progesterone receptor modulator (PRM), ulipristal acetate (UPA), on endometrial morphology and function.DesignCross-sectional.SettingUniversity Research Institute.Patient(s)Endometrial biopsies from 16 pa…

article 2020
Effects of the levonorgestrel intrauterine system on the endometrium after long-term exposure to mifepristone: Secondary outcomes of a randomized controlled trial
·doi:10.1016/j.ejogrb.2020.06.056

ObjectiveLong-term treatment with progesterone receptor modulators (PRM) is associated with a distinct histological entity termed progesterone receptor modulator associated endometrial changes (PAEC). While accumulating evidence implies tha…

review 2020
Physiology of the Endometrium and Regulation of Menstruation
·doi:10.1152/physrev.00031.2019

The physiological functions of the uterine endometrium (uterine lining) are preparation for implantation, maintenance of pregnancy if implantation occurs, and menstruation in the absence of pregnancy. The endometrium thus plays a pivotal ro…

article 2017
Characterization of Molecular Changes in Endometrium Associated With Chronic Use of Progesterone Receptor Modulators: Ulipristal Acetate Versus Mifepristone
·doi:10.1177/1933719117746764

Ulipristal acetate (UPA) is a selective progesterone receptor modulator (PRM), which is used as an emergency contraceptive in women. Recent studies demonstrated the efficacy of an UPA contraceptive vaginal ring (UPA-CVR) as a blocker of ovu…

review 2015
A review of the endometrial histologic effects of progestins and progesterone receptor modulators in reproductive age women
·doi:10.1016/j.contraception.2015.01.008

This review compares the histologic changes that occur in the endometrium following ovulation and progesterone secretion with contraceptive progestins and progesterone receptor modulators (PRMs) that may be used as contraceptive agents in w…

dataset 2014
Faculty Opinions recommendation of β-Catenin activation contributes to the pathogenesis of adenomyosis through epithelial-mesenchymal transition.
·doi:10.3410/f.718021608.793491629
dataset 2013
Faculty Opinions recommendation of SSEA-1 isolates human endometrial basal glandular epithelial cells: phenotypic and functional characterization and implications in the pathogenesis of endometriosis.
·doi:10.3410/f.718029869.793480436
dataset 2012
Faculty Opinions recommendation of Aberrant expression of metastasis-inducing proteins in ectopic and matched eutopic endometrium of women with endometriosis: implications for the pathogenesis of endometriosis.
·doi:10.3410/f.13484062.14861178
dataset 2012
Faculty Opinions recommendation of Increased activation of the PI3K/AKT pathway compromises decidualization of stromal cells from endometriosis.
·doi:10.3410/f.717963688.793465577
dataset 2011
Faculty Opinions recommendation of Abnormal activation of Ras/Raf/MAPK and RhoA/ROCKII signalling pathways in eutopic endometrial stromal cells of patients with endometriosis.
·doi:10.3410/f.8406958.8862056
2010
Evidence of prokineticin dysregulation in fallopian tube from women with ectopic pregnancy.
Fertility and sterility ·doi:10.1016/j.fertnstert.2009.10.061

ObjectiveTo demonstrate expression and regulation of prokineticins (PROKs) and their receptors (PROKRs) in fallopian tube (FT) from women who are not pregnant and women with ectopic pregnancy (EP).DesignTissue analysis.SettingLarge United K…

dataset 2010
Faculty Opinions recommendation of Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium.
·doi:10.3410/f.6478956.6602054
dataset 2010
Faculty Opinions recommendation of Clinical outcome in diagnostically ambiguous foci of 'gland crowding' in the endometrium.
·doi:10.3410/f.5045957.4981056
dataset 2010
Faculty Opinions recommendation of Treatment of endometriosis with a VEGF-targeted conditionally replicative adenovirus.
·doi:10.3410/f.1255979.1111055
2010
Interleukin-11 in endometrial adenocarcinoma is regulated by prostaglandin F2alpha-F-prostanoid receptor interaction via the calcium-calcineurin-nuclear factor of activated T cells pathway and negatively regulated by the regulator of calcineurin-1.
The American Journal of Pathology ·doi:10.2353/ajpath.2010.090403

Interleukin-11 (IL-11) up-regulates the proliferative and invasive capacity of many cancers. Coexpression of glycoprotein 130 (GP130) and IL-11 receptor alpha (IL-11Ralpha) is necessary for high-affinity binding of IL-11 to IL-11Ralpha. Thi…

2009
Attenuated sex steroid receptor expression in fallopian tube of women with ectopic pregnancy.
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2009-1476

ContextSex steroid hormone receptor (SHR) dynamics are well-documented in human endometrium but have not been comprehensively studied in Fallopian tube (FT).ObjectiveThe aim of the study was to compare expression patterns and hormonal regul…

dataset 2009
Faculty Opinions recommendation of Diagnosis of endometriosis by detection of nerve fibres in an endometrial biopsy: a double blind study.
·doi:10.3410/f.1164372.626108
dataset 2009
Faculty Opinions recommendation of Endometrial changes from short-term therapy with CDB-4124, a selective progesterone receptor modulator.
·doi:10.3410/f.1148261.605411
dataset 2009
Faculty Opinions recommendation of Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms.
·doi:10.3410/f.1161710.623298
dataset 2008
Faculty Opinions recommendation of A new role for activin in endometrial repair after menses.
·doi:10.3410/f.1138927.596022
dataset 2008
Faculty Opinions recommendation of Endometriosis is associated with aberrant endometrial expression of telomerase and increased telomere length.
·doi:10.3410/f.1109156.565039
other 2008
The spectrum of endometrial pathology induced by progesterone receptor modulators
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc ·doi:10.1038/modpathol.2008.19

Progesterone receptor modulators (PRM) are hormonally active drugs effective in the management of endometriosis and uterine leiomyomata. The endometrial effects of progestin blockade by PRMs in premenopausal women are currently being evalua…

article 2003
Effect of long-term treatment with low-dose mifepristone on the endometrium
·doi:10.1093/humrep/deg022

BACKGROUND: Mifepristone in low daily doses has contraceptive potential by inhibiting ovulation and menstruation. Because follicular development is maintained, the endometrium is exposed to estrogen for prolonged periods unopposed by proges…