Liu C

PURPOSE: This study aimed to develop and validate a robust multicenter deep learning pipeline that integrates radiomic descriptors with deep feature embeddings to enable comprehensive ovarian tumor analysis from ultrasound imaging, encompas…

BACKGROUND: Ovarian clear cell carcinoma (OCCC) is a rare histological subtype of ovarian cancer, often associated with endometrial lesions, and characterized by poor prognosis and a high propensity for recurrence and metastasis. This study…

ObjectiveTo investigate the value of blood-brain barrier (BBB) injury markers [S100β protein, matrix metalloproteinase-9 (MMP-9), cerebrospinal fluid/serum albumin ratio (QAlb)] and peripheral inflammatory markers [tumor necrosis factor-α (…

BACKGROUND: Circadian rhythm disturbances are known to impair ovarian reserve through endocrine and molecular pathways. However, the specific impact of daytime napping as a common compensatory sleep behavior remains poorly understood. METHO…

[This corrects the article DOI: 10.3389/fendo.2025.1561673.].

OBJECTIVES: To compare the differences in clinical characteristics between different types of abdominal wall endometriosis (AWE) according to the invasive levels of tissue mass. METHODS: 122 patients, who had undergone resection of AWE les…

Patients with endometriosis have greater risk of infertility, which is associated with compromised ovarian function. Dysfunction in follicular granulosa cells and hyperactivation of oestrogen receptor beta (ERβ) are evident in endometriosis…

Extracellular vesicles (EVs) in the mammalian oviduct constitute a key maternal regulatory system that maintains redox balance during early embryogenesis, yet their molecular cargo and functional relevance in human embryos remain poorly def…

Reproduction requires the innate immune system to perform two opposing tasks simultaneously: prevent microbial invasion while preserving tolerance to sperm, the semi-allogeneic embryo, and the developing fetus. This review proposes a unifie…

The paradigm shift of lactate from a mere metabolic byproduct to a pleiotropic signaling molecule, coupled with the discovery of lactylation, provides a crucial framework for understanding how metabolic reprogramming drives systemic patholo…

Urological malignancies represent a group of highly aggressive tumors with a strong tendency toward therapy resistance. Their pathogenesis is closely associated with metabolic reprogramming and epigenetic regulation. In recent years, lactyl…

Diminished ovarian reserve (DOR) is characterized by a decline in oocyte quantity and/or quality and represents a growing cause of female infertility, particularly among young women, yet its pathogenesis remains incompletely understood. Dis…

BACKGROUND: Polycystic ovarian syndrome (PCOS) is a prevalent endocrine disorder in women of reproductive age. Furthermore, the potential risks of long-term use of combined oral contraceptives (COCs) on ovarian reserve function remain uncle…

Acute severe joint pain is a major symptom in gouty arthritis (GA), and its adequate treatment represents an unmet medical need. Mrgprb2, a specific mast cell receptor, has been implicated in the generation of chronic pain by mobilizing mas…

INTRODUCTION: Early pregnancy bleeding is a common pregnancy complication, yet its genetic basis and potential links with psychiatric traits remain poorly understood. This study aimed to characterize the shared genetic architecture between …

Heart failure (HF) is an important cause of morbidity and mortality worldwide. Here, we aimed to screen potent regulators in HF progression to assist clinicians in the early diagnosis and management of HF patients. The data were downloaded …

Calcitonin gene-related peptide (CGRP), a neuropeptide, has been implicated in autoimmune diseases, endometriosis, tumors, and primary headaches, including migraine. The development of a novel, fast-acting CGRP receptor antagonist administe…

BACKGROUND: Global efforts to eliminate cervical cancer currently focus on expanding access to human papillomavirus (HPV) vaccination and cervical screening. However, these efforts lack equal investment in the treatment of precancerous cerv…

Exogenous gonadotropin-based estrus synchronization is widely used in livestock reproduction. However, this hormonal treatment has been associated with adverse reproductive outcomes, suggesting that it may alter the uterine environment and …

BACKGROUND: Unexplained recurrent spontaneous abortion (URSA) poses a significant clinical challenge with an elusive pathogenesis. FABP4 is crucial for lipid homeostasis and placental development, but its specific role and regulatory mechan…

Background: This review aims to systematically summarize the lineage origins, subtype classification, and functional dynamics of endometrial macrophages, clarify their mechanisms of action in normal reproductive physiology (menstrual cycle,…

Ovarian endometriosis (OEM) is characterised by ectopic endometrial tissue growth within the ovary. In these ectopic lesions, the ectopic epithelium plays a crucial role in OEM progression and has been associated with malignant transformati…

BACKGROUND: Gynecological diseases, such as polycystic ovary syndrome (PCOS) and endometriosis, are prevalent global health concerns. Conventional diagnostics often rely on invasive procedures or costly imaging, limiting accessibility in re…

Traditional view holds that the uterus is a sterile environment. However, with the increased development of molecular biology technologies, this classical theory has been re-examined. Increasing evidence shows that a low-biomass, uniquely s…