Férec C

ORCID: 0000-0002-2325-0710 · 3 papers in corpus
2013
Variants in CPA1 are strongly associated with early onset chronic pancreatitis.
Nature genetics ·doi:10.1038/ng.2730

Chronic pancreatitis is an inflammatory disorder of the pancreas. We analyzed CPA1, encoding carboxypeptidase A1, in subjects with nonalcoholic chronic pancreatitis (cases) and controls in a German discovery set and three replication sets. …

2011
Assessing the pathological relevance of SPINK1 promoter variants.
European journal of human genetics : EJHG ·doi:10.1038/ejhg.2011.79

The SPINK1 gene, encoding the human pancreatic secretory trypsin inhibitor, is one of the major genes involved in predisposition to chronic pancreatitis (CP). In this study we have assessed the potential functional impact of 11 SPINK1 promo…

2006
A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis.
Nature genetics ·doi:10.1038/ng1797

Chronic pancreatitis is a common inflammatory disease of the pancreas. Mutations in the genes encoding cationic trypsinogen (PRSS1) and the pancreatic secretory trypsin inhibitor (SPINK1) are associated with chronic pancreatitis. Because in…