Moalli PA

IMPORTANCE: Like polypropylene mesh complications, endometriosis is characterized by inflammation and pain. Chronic pelvic pain is overrepresented in patients with mesh complications. It is unknown whether endometriosis specifically is a ri…

ImportanceForty percent of patients with urogynecologic mesh pain complications are taking narcotics.ObjectivesWe aimed to compare comorbidities and pain scores between patients with and without narcotic use and assess postoperative narcoti…

BackgroundDiabetes is an independent risk factor for mesh complications in women undergoing mesh-augmented surgical repairs of stress urinary incontinence and/or pelvic organ prolapse. The underlying mechanism remains unclear.ObjectiveThis …

ObjectiveThe impact of polypropylene mesh implantation on vaginal collagen and elastin metabolism was analyzed using a nonhuman primate model to further delineate the mechanism of mesh induced complications.Study designForty-nine middle-age…

As a key degrader of fibrillar collagens, matrix metalloproteinase 13 (MMP13), may contribute to the progression of pelvic organ prolapse. Here we aimed to define the regulation of MMP13 by estradiol and progesterone in the vaginal supporti…