ObjectiveTo investigate the effect of antiangiogenic treatment on experimental endometriotic lesion nerve fibers.DesignHeterologous mouse model of endometriosis.SettingUniversity Institute IVI, University Hospital La Fe.Animal(s)Ovariectomi…
Previous studies in an experimental mouse model of endometriosis have shown that the dopamine agonist (DA) cabergoline (Cb2) reduces angiogenesis and endometriotic lesions, hypothetically binding to the dopamine receptor type-2 (DRD2). To d…
BACKGROUND: Implantation of a retrogradely-shed endometrium during menstruation requires an adequate blood supply. The endometrium has angiogenic potential, and endometriotic lesions grow in areas with a rich vascularization, suggesting tha…
Survival of newly implanted retrograde–shed endometrial tissue during menstruation in an ectopic location requires an adequate blood supply. This suggests that angiogenesis is a prerequisite for the development of endometriosis and that its…