Brooke E. Howitt

Mesonephric-like adenocarcinoma (MLA) is a rare and aggressive gynecologic malignancy that has only been recognized in the last decade. It arises in the endometrium, ovaries, and other extrauterine sites (often in association with endometri…

The Hippo pathway regulates many physiological processes, including development, tumor suppression, and wound healing. One understudied Hippo pathway component is PTPN14, an evolutionarily conserved tyrosine phosphatase that inhibits YAP/TA…

Mesonephric adenocarcinomas (MAs) and mesonephric-like adenocarcinomas (MLAs) are rare, aggressive neoplasms that arise in the gynecologic tract and show overlapping morphologic, immunohistochemical, and molecular features. While MAs occur …

AimsSTK11 adnexal tumour is a rare, recently described malignant neoplasm that is associated with Peutz-Jeghers syndrome. [Correction added on 3 October 2024, after first online publication: 'ST11' in preceding sentence has been corrected t…

Supplemental Figure 1: Kaplan Meier Survival Curves by TCGA Molecular Subtype

Supplemental Figure 1: Kaplan Meier Survival Curves by TCGA Molecular Subtype

Supplemental Figure 2: Schoenfeld’s test of proportional hazards for multivariate Cox analysis including CINSARC and EcoTyper Classifiers.

Supplemental Figure 2: Schoenfeld’s test of proportional hazards for multivariate Cox analysis including CINSARC and EcoTyper Classifiers.

Supplemental Figure 3: EERI Values in TCGA Subtypes. A) The Stanford-EEC cohort and subgroups. B) The TCGA-UCEC cohort and subgroups. P-values generated by Whitney-Mann U test. Error bars represent 95% confidence intervals.

Supplemental Figure 3: EERI Values in TCGA Subtypes. A) The Stanford-EEC cohort and subgroups. B) The TCGA-UCEC cohort and subgroups. P-values generated by Whitney-Mann U test. Error bars represent 95% confidence intervals.

Supplemental Figure 4: Recurrence Free Survival stratified by EERI score for Stages I-IV disease in the TCGA-UCEC Cohort. Patients with EEC by stage at diagnosis. Patients were included with more than 1 year of follow-up and known endometri…

Supplemental Figure 4: Recurrence Free Survival stratified by EERI score for Stages I-IV disease in the TCGA-UCEC Cohort. Patients with EEC by stage at diagnosis. Patients were included with more than 1 year of follow-up and known endometri…

Supplemental Table 1: Genes used in EERI listed by prognostic impact.

Supplemental Table 1: Genes used in EERI listed by prognostic impact.

Supplemental Table 2: Clinical and Pathologic Variables of Cases and EERI False Negatives in both the Stanford-EEC cases and TCGA-UCEC recurrent patients

Supplemental Table 2: Clinical and Pathologic Variables of Cases and EERI False Negatives in both the Stanford-EEC cases and TCGA-UCEC recurrent patients

Supplemental Table 3: Clinical and Pathologic Variables of Controls and EERI False Positives in both the Stanford-EEC controls and TCGA-UCEC non-recurrent patients

Supplemental Table 3: Clinical and Pathologic Variables of Controls and EERI False Positives in both the Stanford-EEC controls and TCGA-UCEC non-recurrent patients

Clear cell carcinomas are rare and relatively chemo-insensitive ovarian cancers with a characteristic molecular pathogenesis. Alterations in ARID1A, a component of the multiprotein chromatin remodeling complex SWI/SNF, are likely early even…

Mesonephric adenocarcinoma (MA) and mesonephric-like adenocarcinoma (MLA) are uncommon neoplasms of the gynecologic tract that have until recently been poorly understood. Although their morphologic, immunohistochemical, and molecular profil…

Intravenous leiomyomatosis (IVL) is a quasi-malignant smooth muscle tumor involving lymphatic and venous spaces of the myometrium. Rare cases of IVL with admixed endometrial glands and stroma have been described, termed intravascular adenom…

Endometriosis is generally histopathologically defined as the presence of at least 2 of the following: endometrial stroma, Müllerian epithelium, and/or hemosiderin-laden macrophages (HLM). Despite clinically evident endometriotic lesions, b…

High-grade neuroendocrine carcinomas (NEC) of the endometrium are rare and account for <1% of all endometrial carcinomas. Both small cell neuroendocrine carcinoma (SCNEC) and large cell neuroendocrine carcinoma (LCNEC) morphologies have bee…

The current World Health Organization (WHO) classification for endocervical adenocarcinoma (EA) is based on descriptive morphologic characteristics; however, it does not fully reflect our current knowledge of the diverse pathogenesis of cer…