U Saarela

ORCID: 0000-0002-9410-6548 · 3 papers in corpus
other 2026
The impact of menstrual cycle phase and BMI on mitochondrial dysfunction in PMOS endometrium
Human Reproduction ·doi:10.1093/humrep/deag127

STUDY QUESTION: Does the endometrium of oligo-ovulatory women with polyendocrine metabolic ovarian syndrome (PMOS) exhibit menstrual cycle phase-specific transcriptomic alterations compared to women without PMOS? SUMMARY ANSWER: Compared t…

other 2025
PCOS endometrium-derived epithelial organoids as a novel model to study endometrial dysfunction
Human Reproduction ·doi:10.1093/humrep/deaf113

STUDY QUESTION: Are we able to establish endometrium epithelial organoids (EEOs) from endometrial samples obtained from women with PCOS, and do they differ from non-PCOS EEOs? SUMMARY ANSWER: We were able to establish, for the first time, …

2024
Induced Pluripotent Stem Cells as a Possible Approach for Exploring the Pathophysiology of Polycystic Ovary Syndrome (PCOS).
Stem cell reviews and reports ·doi:10.1007/s12015-023-10627-w

Polycystic ovary syndrome (PCOS) is the most prevalent endocrine condition among women with pleiotropic sequelae possessing reproductive, metabolic, and psychological characteristics. Although the exact origin of PCOS is elusive, it is know…