Siddhanath Metkari

ORCID: 0000-0001-9179-2004 · 4 papers in corpus
lab-animal 2022
Additional evidence to support OCT-4 positive VSELs and EnSCs as the elusive tissue-resident stem/progenitor cells in adult mice uterus
Stem cell research & therapy ·doi:10.1186/s13287-022-02703-8

OBJECTIVE: True identity and specific set of markers to enrich endometrial stem cells still remains elusive. Present study was undertaken to further substantiate that very small embryonic-like stem cells (VSELs) are the true and elusive ste…

lab-animal 2021
Mice Uterine Stem Cells are Affected by Neonatal Endocrine Disruption & Initiate Uteropathies in Adult Life Independent of Circulatory Ovarian Hormones
Stem cell reviews and reports ·doi:10.1007/s12015-021-10279-8

It is generally believed that ovarian hormones regulate uterine functions and their altered levels result in various uteropathies like non-receptive uterus, endometrial hyperplasia, adenomyosis, endometriosis, leiomyomas and cancer. Uterus …

lab-animal 2016
Adenoviral vector encoding soluble Flt-1 engineered human endometrial mesenchymal stem cells effectively regress endometriotic lesions in NOD/SCID mice
Gene therapy ·doi:10.1038/gt.2016.30

This study was undertaken to study the efficiency of Adsflt-1 engineered human eutopic mesenchymal stem cells (MSCs) secreting anti-angiogenic sFlt-1 as a targeted cell-based therapy for endometriosis (EM). Eutopic MSCs were transduced with…

lab-animal 2015
Very small embryonic-like stem cells are the elusive mouse endometrial stem cells--a pilot study
Journal of ovarian research ·doi:10.1186/s13048-015-0138-2

BACKGROUND: Endometrium undergoes dramatic growth, breakdown and regeneration throughout reproductive period in mammals. Stem cells have been implicated in the process however their origin, nature, anatomical localization and characterizati…